Eph receptors and ephrins as targets for cancer therapy

Journal of Cellular and Molecular Medicine

Hong-Qing Xi¹  Xiao-Song Wu¹  Bo Wei¹ 

[1] Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing, China

关键词: Eph receptor;    Ephrin;    therapeutic target;   

DOI  :  10.1111/j.1582-4934.2012.01612.x

来源: Wiley

【 摘 要 】

Abstract

Eph receptor tyrosine kinases and their ephrin ligands are involved in various signalling pathways and mediate critical steps of a wide variety of physiological and pathological processes. Increasing experimental evidence demonstrates that both Eph receptor and ephrin ligands are overexpressed in a number of human tumours, and are associated with tumour growth, invasiveness and metastasis. In this regard, the Eph/ephrin system provides the foundation for potentially exciting new targets for anticancer therapies for Eph-expressing tumours. The purpose of this review is to outline current advances in the role of Eph receptors and ephrin ligands in cancer, and to discuss novel therapeutic approaches of anticancer therapies.

【 授权许可】

Unknown   
© 2012 The Authors Journal of Cellular and Molecular Medicine © 2012 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd