Histamine: an undercover agent in multiple rare diseases?

Journal of Cellular and Molecular Medicine

Almudena Pino-Ángeles¹  Armando Reyes-Palomares¹  Esther Melgarejo¹ 

[1] Dpto. Biología Molecular y Bioquímica, Universidad de Málaga, Málaga, Spain

关键词: histamine;    histamine receptors;    rare diseases;    systems biology;   

DOI  :  10.1111/j.1582-4934.2012.01566.x

来源: Wiley

【 摘 要 】

Abstract

Histamine is a biogenic amine performing pleiotropic effects in humans, involving tasks within the immune and neuroendocrine systems, neurotransmission, gastric secretion, cell life and death, and development. It is the product of the histidine decarboxylase activity, and its effects are mainly mediated through four different G-protein coupled receptors. Thus, histamine-related effects are the results of highly interconnected and tissue-specific signalling networks. Consequently, alterations in histamine-related factors could be an important part in the cause of multiple rare/orphan diseases. Bearing this hypothesis in mind, more than 25 rare diseases related to histamine physiopathology have been identified using a computationally assisted text mining approach. These newly integrated data will provide insight to elucidate the molecular causes of these rare diseases. The data can also help in devising new intervention strategies for personalized medicine for multiple rare diseases.

【 授权许可】

Unknown   
© 2012 The Authors Journal of Cellular and Molecular Medicine © 2012 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd