Potential biomarkers in psychiatry: focus on the cholesterol system

Journal of Cellular and Molecular Medicine

Alisa G. Woods²  Izabela Sokolowska²  Regina Taurines⁴  Manfred Gerlach⁴  Edward Dudley¹  Johannes Thome³ 

[1] Academic Unit of Psychiatry, Institute of Life Science, School of Medicine, Swansea University, Swansea, UK;Department of Chemistry & Biomolecular Science, Biochemistry & Proteomics Group, Clarkson University, Potsdam, NY, USA;Department of Psychiatry, University of Rostock, Rostock, Germany;Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Germany

关键词: apolipoprotein;    Apos;    autism;    biomarker;    cholesterol;    proteomics;   

DOI  :  10.1111/j.1582-4934.2012.01543.x

来源: Wiley

【 摘 要 】

Abstract

● Introduction

● Methods for proteomic analysis

– Sample fractionation/biochemical fractionation

– MS

● The cholesterol system

– Cholesterol and apolipoproteins

– Cholesterol

– Apos

– ApoE

– ApoB

– ApoA1 and ApoA4

● The cholesterol system and specific disorders

– Alzheimer's disease

– Schizophrenia

– Depression

– Developmental disorders: ASDs

● Discussion

– Proteomic considerations for analysis of Apos

– Considering diet and lifestyle effects on the cholesterol system

– Consequences of disturbed cholesterol and Apos in the CNS

● Conclusion

Measuring biomarkers to identify and assess illness is a strategy growing in popularity and relevance. Although already in clinical use for treating and predicting cancer, no biological measurement is used clinically for any psychiatric disorder. Biomarkers could predict the course of a medical problem, and aid in determining how and when to treat. Several studies have indicated that of candidate psychiatric biomarkers detected using proteomic techniques, cholesterol and associated proteins, specifically apolipoproteins (Apos), may be of interest. Cholesterol is necessary for brain development and its synthesis continues at a lower rate in the adult brain. Apos are the protein component of lipoproteins responsible for lipid transport. There is extensive evidence that the levels of cholesterol and Apos may be disturbed in psychiatric disorders, including autistic spectrum disorders (ASD). Here, we describe putative serum biomarkers for psychiatric disorders, and the role of cholesterol and Apos in central nervous system (CNS) disorders.

【 授权许可】

Unknown   
© 2012 The Authors Journal of Cellular and Molecular Medicine © 2012 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd