The Need for Objective Measures of Stress in Autism

Frontiers in Psychology

Cédric Hufnagel¹ 

关键词: stress;    anxiety;    biomarker;    autism;    heart rate variability;    objective measures;   

DOI  :  10.3389/fpsyg.2017.00064

学科分类：心理学（综合）

来源: Frontiers

【 摘 要 】

Previous literature have reported either normal or impaired baseline HRV in people with autism spectrum disorder (Cheshire, 2012; Kushki et al., 2014). Similarly, even if people with autism and healthy controls may share similar pattern of autonomic modifications following an acute mental stress (Kushki et al., 2014), some authors also reported a blunted HRV response to an acute stress (Hollocks et al., 2014, 2016). Despite the responses were still linked with stress, methods to analyze HRV response are questionable. Electrocardiogram recording are typically segmented into a priori blocks of 5 min each or other a priori fixed period of time. Our change point method is statistically different. We detect the abrupt change, then we calculate the mean value of HRV between two consecutive abrupt changes (Figure ​(Figure1).1). The detection of abrupt changes is a statistical approach based on an individual basis and not on a population normalized level. There is no need for a control group. Personalized statistics are computed within the time-series of each individual, precluding bias. Detection of abrupt changes has a short history in medicine but a long history in quantitative finance, which has led to several Nobel prizes (Mandelbrot, 1963; Engle and Granger, 1982; Hansen, 1982; Granger, 2004).

【 授权许可】

CC BY