Epidemiological and virological characteristics of influenza B: results of the Global Influenza B Study

Influenza and Other Respiratory Viruses

Saverio Caini²³  Q. Sue Huang²  Meral A. Ciblak⁷  Gabriela Kusznierz¹⁶  Rhonda Owen¹  Sonam Wangchuk¹⁵  Cláudio M. P. Henriques¹³  Richard Njouom¹⁷  Rodrigo A. Fasce⁹  Hongjie Yu^19,23  Luzhao Feng^19,23  Maria Zambon^18,23  Alexey W. Clara^10,23  Herman Kosasih^6,23  Simona Puzelli^20,23  Herve A. Kadjo^4,23  Gideon Emukule^22,23  Jean-Michel Heraud^11,23  Li Wei Ang^21,23  Marietjie Venter^5,23  Alla Mironenko^2,8  Lynnette Brammer^2,12  Le Thi Quynh Mai^2,14  François Schellevis²³  Stanley Plotkin^2,3  John Paget²³ 

[1] Department of Health and Ageing, Influenza Surveillance Section, Surveillance Branch, Office of Health Protection, Woden, ACT, Australia;Institute of Environmental Science and Research, Wellington, New Zealand;University of Pennsylvania, Philadelphia, PA, USA;Respiratory Viruses Unit, Pasteur Institute of Côte d'Ivoire, Abidjan, Côte d'Ivoire;Global Disease Detection, US-CDC, Pretoria, South Africa;US Naval Medical Research Unit No. 2, Jakarta, Indonesia;Istanbul University, Istanbul, Turkey;L.V.Gromashevsky Institute of Epidemiology and Infectious Diseases National Academy of Medical Science of Ukraine, Kiev, Ukraine;Sección de Virus Respiratorios y Exantemáticos, Instituto de Salud Pública de Chile, Santiago de Chile, Chile;US Centers for Disease Control, Central American Region, Guatemala City, Guatemala;National Influenza Center, Virology Unit, Institut Pasteur of Madagascar, Antananarivo, Madagascar;Epidemiology and Prevention Branch, Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA;Ministry of Health, Brasília, DF, Brazil;National Institute of Hygiene and Epidemiology, Hanoi, Vietnam;Public Health Laboratory, Department of Public Health, Ministry of Health, Thimphu, Bhutan;Instituto Nacional de Enfermedades Respiratorias Dr. Emilio Coni, Santa Fe, Argentina;Service de Virologie, Centre Pasteur du Cameroun, Yaounde, Cameroon;Respiratory Virus Unit, Public Health England, Colindale, UK;Division of Infectious Disease, Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China;National Influenza Center, Istituto Superiore Sanità, Rome, Italy;Epidemiology and Disease Control Division, Ministry of Health, Singapore, Singapore;US Centers for Disease Control and Prevention, Nairobi, Kenya;Netherlands Institute for Health Services Research (NIVEL), Utrecht, The Netherlands

关键词: Burden of disease;    epidemiology;    Global Influenza B Study (GIBS);    influenza;    vaccination;    vaccine mismatch;   

DOI  :  10.1111/irv.12319

来源: Wiley

【 摘 要 】

Abstract

Introduction

Literature on influenza focuses on influenza A, despite influenza B having a large public health impact. The Global Influenza B Study aims to collect information on global epidemiology and burden of disease of influenza B since 2000.

Methods

Twenty-six countries in the Southern (n = 5) and Northern (n = 7) hemispheres and intertropical belt (n = 14) provided virological and epidemiological data. We calculated the proportion of influenza cases due to type B and Victoria and Yamagata lineages in each country and season; tested the correlation between proportion of influenza B and maximum weekly influenza-like illness (ILI) rate during the same season; determined the frequency of vaccine mismatches; and described the age distribution of cases by virus type.

Results

The database included 935 673 influenza cases (2000–2013). Overall median proportion of influenza B was 22·6%, with no statistically significant differences across seasons. During seasons where influenza B was dominant or co-circulated (>20% of total detections), Victoria and Yamagata lineages predominated during 64% and 36% of seasons, respectively, and a vaccine mismatch was observed in ≈25% of seasons. Proportion of influenza B was inversely correlated with maximum ILI rate in the same season in the Northern and (with borderline significance) Southern hemispheres. Patients infected with influenza B were usually younger (5–17 years) than patients infected with influenza A.

Conclusion

Influenza B is a common disease with some epidemiological differences from influenza A. This should be considered when optimizing control/prevention strategies in different regions and reducing the global burden of disease due to influenza.

【 授权许可】

CC BY-NC   
© 2015 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.

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