The substantial hospitalization burden of influenza in central China: surveillance for severe, acute respiratory infection, and influenza viruses, 2010–2012

Influenza and Other Respiratory Viruses

Hongjie Yu⁸  Jigui Huang²  Yang Huai⁵  Xuhua Guan⁹  John Klena⁵  Shali Liu⁶  Youxing Peng¹¹  Hui Yang⁷  Jun Luo¹  Jiandong Zheng⁸  Maoyi Chen²  Zhibin Peng⁸  Nijuan Xiang¹⁰  Xixiang Huo⁹  Lin Xiao²  Hui Jiang⁸  Hui Chen⁹  Yuzhi Zhang⁵  Xuesen Xing⁹  Zhen Xu⁸  Zijian Feng¹⁰  Faxian Zhan⁹  Weizhong Yang^3,8  Timothy M. Uyeki^4,8  Yu Wang^3,8 

[1] Jingzhou Maternal and Children's Hospital, Jingzhou, China;Jingzhou Center for Disease Control and Prevention, Jingzhou, China;Chinese Center for Disease Control and Prevention, Beijing, China;Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA;China-US Collaborative Program on Emerging and Re-emerging Infection Disease, US Centers for Disease Control and Prevention, Beijing, China;Jingzhou Central Hospital, Jingzhou, China;Jingzhou Second People's Hospital, Jingzhou, China;Divison of Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing, China;Hubei Provincial Centre for Disease Control and Prevention, Wuhan, China;Public Health Emergency Center, Chinese Center for Disease Control and Prevention, Beijing, China;Jingzhou First People's Hospital, Jingzhou, China

关键词: China;    disease burden;    influenza;    seasonality;   

DOI  :  10.1111/irv.12205

来源: Wiley

【 摘 要 】

Abstract

Background

Published data on influenza in severe acute respiratory infection (SARI) patients are limited. We conducted SARI surveillance in central China and estimated hospitalization rates of SARI attributable to influenza by viral type/subtype.

Methods

Surveillance was conducted at four hospitals in Jingzhou, China from 2010 to 2012. We enrolled hospitalized patients who had temperature ≥37·3°C and at least one of: cough, sore throat, tachypnea, difficulty breathing, abnormal breath sounds on auscultation, sputum production, hemoptysis, chest pain, or chest radiograph consistent with pneumonia. A nasopharyngeal swab was collected from each case-patient within 24 hours of admission for influenza testing by real-time reverse transcription PCR.

Results

Of 17 172 SARI patients enrolled, 90% were aged <15 years. The median duration of hospitalization was 5 days. Of 16 208 (94%) SARI cases tested, 2057 (13%) had confirmed influenza, including 1427 (69%) aged <5 years. Multiple peaks of influenza occurred during summer, winter, and spring months. Influenza was associated with an estimated 115 and 142 SARI hospitalizations per 100 000 during 2010–2011 and 2011–2012 [including A(H3N2): 55 and 44 SARI hospitalizations per 100 000; pandemic A(H1N1): 33 SARI hospitalizations per 100 000 during 2010–2011; influenza B: 26 and 98 hospitalizations per 100 000], with the highest rate among children aged 6–11 months (3603 and 3805 hospitalizations per 100 000 during 2010–2011 and 2011–2012, respectively).

Conclusions

In central China, influenza A and B caused a substantial number of hospitalizations during multiple periods each year. Our findings strongly suggest that young children should be the highest priority group for annual influenza vaccination in China.

【 授权许可】

CC BY   
© 2013 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.

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