Cellular and molecular determinants of all‐trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression

EMBO Molecular Medicine

Floriana Centritto⁴  Gabriela Paroni⁴  Marco Bolis⁴  Silvio Ken Garattini⁴  Mami Kurosaki⁴  Maria Monica Barzago⁴  Adriana Zanetti⁴  James Neil Fisher⁴  Mark Francis Scott⁴  Linda Pattini³  Monica Lupi²  Paolo Ubezio²  Francesca Piccotti⁶  Alberto Zambelli¹  Paola Rizzo⁵  Maurizio Gianni'⁴  Maddalena Fratelli⁴  Mineko Terao⁴ 

[1] Oncologia Medica, Ospedale Papa Giovanni XXIII, Bergamo, Italy;Department of Oncology, IRCCS-Istituto di Ricerche Farmacologiche “Mario Negri”, Milano, Italy;Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy;Laboratory of Molecular Biology, IRCCS-Istituto di Ricerche Farmacologiche “Mario Negri”, Milano, Italy;Gene Therapy and Cellular Reprogramming, IRCCS- Istituto di Ricerche Farmacologiche “Mario Negri”, Bergamo, Italy;IRCCS-Fondazione “Salvatore Maugeri”, Pavia, Italy

关键词: breast cancer;    luminal phenotype;    nuclear receptor;    RARalpha;    retinoic acid;   

DOI  :  10.15252/emmm.201404670

来源: Wiley

【 摘 要 】

Forty-two cell lines recapitulating mammary carcinoma heterogeneity were profiled for all-trans retinoic acid (ATRA) sensitivity. Luminal and ER⁺ (estrogen-receptor-positive) cell lines are generally sensitive to ATRA, while refractoriness/low sensitivity is associated with a Basal phenotype and HER2 positivity. Indeed, only 2 Basal cell lines (MDA-MB157 and HCC-1599) are highly sensitive to the retinoid. Sensitivity of HCC-1599 cells is confirmed in xenotransplanted mice. Short-term tissue-slice cultures of surgical samples validate the cell-line results and support the concept that a high proportion of Luminal/ER⁺ carcinomas are ATRA sensitive, while triple-negative (Basal) and HER2-

【 授权许可】

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© 2015 The Authors. Published under the terms of the CC BY 4.0 license

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