Evolving targets for lipid‐modifying therapy

EMBO Molecular Medicine

Rose Q Do²  Stephen J Nicholls¹ 

[1] South Australian Health and Medical Research Institute and University of Adelaide, Adelaide, SA, Australia;VA Medical Center, University of Colorado School of Medicine, Denver, CO, USA

关键词: atherosclerosis;    cholesterol;    lipoproteins;    triglycerides;   

DOI  :  10.15252/emmm.201404000

来源: Wiley

【 摘 要 】

Abstract

The pathogenesis and progression of atherosclerosis are integrally connected to the concentration and function of lipoproteins in various classes. This review examines existing and emerging approaches to modify low-density lipoprotein and lipoprotein (a), triglyceride-rich lipoproteins, and high-density lipoproteins, emphasizing approaches that have progressed to clinical evaluation. Targeting of nuclear receptors and phospholipases is also discussed.

【 授权许可】

CC BY   
© 2014 The Authors. Published under the terms of the CC BY 4.0 license

Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.