Lipid Profile Is Negatively Associated with Uremic Toxins in Patients with Kidney Failure—A Tri-National Cohort

Toxins

卷:14

Joachim Beige¹  Peter Stenvinkel²  Karolina Kublickiene²  Sam Hobson²  Thomas Ebert²  Henriette de Loor³  Pieter Evenepoel³ 

[1] Division of Nephrology and KfH Renal Unit, Hospital St. Georg, 04129 Leipzig, Germany;

[2] Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, SE-17177 Stockholm, Sweden;

[3] Nephrology and Renal Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, Katholieke Universiteit Leuven, BE-3000 Leuven, Belgium;

关键词: cholesterol;    lipids;    lipoproteins;    renal disease;    triglycerides;    uremic retention solutes;   

DOI  :  10.3390/toxins14060412

来源: DOAJ

【 摘 要 】

Patients with kidney failure (KF) have a high incidence of cardiovascular (CV) disease, partly driven by insufficient clearance of uremic toxins. Recent investigations have questioned the accepted effects of adverse lipid profile and CV risk in uremic patients. Therefore, we related a panel of uremic toxins previously associated with CV morbidity/mortality to a full lipid profile in a large, tri-national, cross-sectional cohort. Total, high-density lipoprotein (HDL), non-HDL, low-density lipoprotein (LDL), and remnant cholesterol, as well as triglyceride, levels were associated with five uremic toxins in a cohort of 611 adult KF patients with adjustment for clinically relevant covariates and other patient-level variables. Univariate analyses revealed negative correlations of total, non-HDL, and LDL cholesterol with all investigated uremic toxins. Multivariate linear regression analyses confirmed independent, negative associations of phenylacetylglutamine with total, non-HDL, and LDL cholesterol, while indole-3 acetic acid associated with non-HDL and LDL cholesterol. Furthermore, trimethylamine-N-Oxide was independently and negatively associated with non-HDL cholesterol. Sensitivity analyses largely confirmed findings in the entire cohort. In conclusion, significant inverse associations between lipid profile and distinct uremic toxins in KF highlight the complexity of the uremic milieu, suggesting that not all uremic toxin interactions with conventional CV risk markers may be pathogenic.

【 授权许可】

Unknown