Autophagic control of cell ‘stemness’

EMBO Molecular Medicine

Huize Pan²  Ning Cai²  Mo Li³  Guang-Hui Liu¹ 

[1] E-mail address: 关键词: autophagy;    cellular reprogramming;    iPSC;    stem cells;    stemness;   

DOI  :  10.1002/emmm.201201999

来源: Wiley

【 摘 要 】

Abstract

Stem cells have the ability to self-renew and differentiate into various cell types. Both cell-intrinsic and extrinsic factors may contribute to aging-related decline in stem cell function and loss of stemness. The maintenance of cellular homeostasis requires timely removal of toxic proteins and damaged organelles that accumulate with age or in pathological conditions. Autophagy is one of the main strategies to eliminate unwanted cytoplasmic materials thereby ultimately preventing cellular damage. Here, we shall discuss the accumulating evidence suggesting that autophagy plays a critical role in the homeostatic control of stem cell functions during aging, tissue regeneration, and cellular reprogramming.

【 授权许可】

Unknown   
Copyright © 2013 The Authors. Published by John Wiley and Sons, Ltd on behalf of EMBO. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.