Polymyxin‐B‐immobilized‐fiber column hemoperfusion with oseltamivir treatment for ARDS due to influenza H1N1/09

Respirology Case Reports

Nguyen Gia Binh²  Toshie Manabe¹  Dao Xuan Co²  Nguyen Dang Tuan²  Pham The Thach² 

[1] Organization for Asian Study, Waseda University, Tokyo, Japan;Intensive Care Unit, Bach Mai Hospital, Hanoi, Vietnam

关键词: Acute respiratory distress syndrome (ARDS);    influenza;    oseltamivir;    PaO2/FiO2;    polymyxin‐B‐immobilized fiber column (PMX‐DHP);   

DOI  :  10.1002/rcr2.100

来源: Wiley

【 摘 要 】

Abstract

Acute respiratory distress syndrome (ARDS) is one of the severe complications of influenza H1N1/09 infection, resulting in high mortality. Effective treatment strategies for ARDS are needed. This report presents two cases of ARDS due to influenza in Vietnam. Both cases were similar in terms of starting symptoms, the rapid progression to ARDS, and the treatment strategy, direct hemoperfusion with a polymyxin-B-immobilized fiber column (PMX-DHP) and oseltamivir. However, the clinical course of disease and the outcomes were different. For case 1, treatment was initiated on day 4 following the onset of hypoxemia due to ARDS. Symptoms improved rapidly after treatment and the patient was discharged on day 12. For case 2, treatment was initiated on day 9 after the onset of symptoms. Despite intensive therapy, the patient died on day 18. In conclusion, treatment with PMX-DHP and oseltamivir is effective on ARDS due to influenza but only if initiated early.

【 授权许可】

CC BY-NC   
© 2015 The Authors. Respirology Case Reports published by John Wiley & Sons Ltd on behalf of The Asian Pacific Society of Respirology.

Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.