Risk Factors and Outcomes in Cats with Acquired Myasthenia Gravis (2001–2012)

Journal of Veterinary Internal Medicine

D.W. Hague¹  H.D. Humphries²  M.A. Mitchell¹ 

[1] College of Veterinary Medicine, University of Illinois, Urbana, IL;Department of Pathology, School of Medicine, University of California, San Diego, CA

关键词: Acetylcholine receptor antibody;    Feline;    Thymoma;   

DOI  :  10.1111/jvim.13596

来源: Wiley

【 摘 要 】

Abstract

Background

Acquired myasthenia gravis (MG) in cats most commonly causes generalized weakness without megaesophagus and is more often associated with a cranial mediastinal mass, compared to dogs.

Hypothesis/Objectives

To extend the clinical findings described in the report of 2000 on MG in cats (J Am Vet Med Assoc 215:55–57).

Animals

Two hundred and thirty-five cats with MG.

Methods

Retrospective case study to evaluate the long-term outcome and incidence of spontaneous remission in myasthenic cats. Information including signalment, clinical presentation, presence of and type of cranial mediastinal mass, treatment including surgical versus medical, survival time, and outcome including spontaneous remissions was collected and analyzed in cats diagnosed at the Comparative Neuromuscular Laboratory, University of California San Diego by detection of acetylcholine receptor antibody titers >0.3 nmol/L by immunoprecipitation radioimmunosassay.

Results

Acquired MG in cats is associated with a euthanasia rate of 58%. Abyssinian and Somali cats had an increased incidence of MG compared to mixed breed cats or cats of other breeds. A cranial mediastinal mass, most commonly thymoma, was observed in 52% of the cats, which is higher than in the previous report. Spontaneous remission is not a characteristic of MG in cats.

Conclusions and clinical importance

Myasthenia gravis in cats is a chronic disease associated with a high incidence of a cranial mediastinal mass. Spontaneous remission is not common and clinicians should warn owners of the necessity for long-term treatment. The clinical outcome with a cranial mediastinal mass did not differ between surgical or medical treatment.

【 授权许可】

CC BY-NC   
Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of American College of Veterinary Internal Medicine.

Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.