期刊论文详细信息
Journal of Veterinary Internal Medicine
Reliability of the i‐STAT for the determination of blood electrolyte (K+, Na+, and CI−) concentrations in cattle
E. Yildirim1  T. Karapinar1 
[1] Department of Internal Medicine, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey
关键词: Accuracy;    Bovine;    Point‐of‐care device;    Precision;    Sensitivity;    Specificity;   
DOI  :  10.1111/jvim.12526
来源: Wiley
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【 摘 要 】

Abstract

Background

Rapid determination of blood electrolyte concentrations can help determine electrolyte status and delivery of effective volume of electrolyte solutions in field conditions.

Objective

To evaluate reliability of the i-STAT, a point-of-care (POC) device, in measuring blood K+, Na+, and CI concentrations in cattle.

Animals

Ninety-eight cattle with various diseases.

Methods

In this prospective study, blood samples collected from the jugular vein were processed for determination of K+, Na+, and CI concentrations in blood and plasma using the i-STAT and auto-analyzer (Cobas C501), respectively. Blood and plasma electrolyte data were subjected to student t-test for comparison, the concordance analysis for agreement, accuracy, and precision, the Passing-Bablok regression and the Bland-Altman plot for reliability, and receiver operating characteristics curves for sensitivity (Se) and specificity (Sp).

Results

Plasma concentrations of K+ (4.39 versus 4.2 mmol/L; < .0001) and CI (100.30 versus 99.4 mmol/L; < .04) were greater than their concentrations in blood. Plasma and blood Na+ concentrations were similar (136.95 versus 136.8 mmol/L). The i-STAT results were highly correlated with the Cobas C501 results (= 0.970, 0.922, and 0.866 for K+, Na+, and CI, respectively). Regression equations fitting blood (Y) and plasma (X) concentration did not deviate from the identity line for K+ (Y = −0.10 + 0.98 × X), Na+ (Y = X), and CI (Y = 3.04 + 0.96 × X). The mean bias (blood concentration - plasma concentration) was −0.20 for K+ (= .03), −0.16 for Na+ (= .12), and −0.87 for CI (= .93). The i-STAT had 76–100% Se and 87.7–100% Sp for assessing electrolyte statuses.

Conclusions and Clinical Importance

The i-STAT yielded results that were in agreement with the auto-analyzer, with negligible biases in measurement of plasma K+, Na+, and CI concentrations. The i-STAT is a reliable POC device and can be used in field condition to assess electrolyte status in cattle.

【 授权许可】

Unknown   
Copyright © 2015 by the American College of Veterinary Internal Medicine

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