Background
Serum cobalamin concentration [CBL] suggests CBL deficiency in cats but serum methylmalonic acid concentration [MMA] more accurately indicates CBL deficiency.
Journal of Veterinary Internal Medicine | |
The Relationship of Serum Cobalamin to Methylmalonic Acid Concentrations and Clinical Variables in Cats | |
P. Worhunsky1  O. Toulza1  M. Rishniw1  N. Berghoff2  C.G. Ruaux2  J.M. Steiner2  | |
[1] College of Veterinary Medicine, Cornell University, Ithaca, NY;Gastrointestinal Laboratory, Texas A&M University, College Station, TX | |
关键词: Diagnostic accuracy; Enteropathy; Gastrointestinal disease; Hepatopathy; Sensitivity; Specificity; Test performance; Vitamin B12; | |
DOI : 10.1111/jvim.12152 | |
来源: Wiley | |
Serum cobalamin concentration [CBL] suggests CBL deficiency in cats but serum methylmalonic acid concentration [MMA] more accurately indicates CBL deficiency. To examine the ability of [CBL] to predict CBL deficiency defined by increased [MMA], and relationships of [CBL] and [MMA] with select clinical and clinicopathological variables. One hundred sixty-three client-owned cats with [CBL] measurements, 114 cats with simultaneous [MMA] measurements; 88 cats with medical information. Prospectively collected [CBL] and [MMA] were compared using scatter plots, receiver operating characteristic and correlative analyses with historical [CBL] thresholds and those identified in the study. [CBL] and [MMA] were compared retrospectively to specific clinical and clinicopathological variables. [CBL] correlated negatively with [MMA] (τ = −0.334, P < .0001). [MMA] ≥ 1,343 nmol/L identified CBL deficiency. [CBL] = 209 pg/mL optimized sensitivity (0.51), specificity (0.96), PPV (0.89), and NPV (0.74) for detecting [MMA] ≥ 1,343 nmol/L. Prevalence of CBL deficiency was 42% (48/114) when defined by [MMA] ≥ 1,343 nmol/L versus 23% (27/114) by [CBL] ≤ 209 pg/mL. Unexpectedly, 23 and 45% of 48 cats with [MMA] ≥ 1,343 nmol/L had [CBL] > 900 pg/mL and 290 pg/mL (historical thresholds). [CBL] correlated with mean corpuscular volume (τ = −0.199, P = .013) and [MMA] with hematocrit (τ = −0.28, P = .006). Cobalamin deficiency ([MMA] ≥ 1,343 nmol/L) occurred in 42% of cats and is predicted with high specificity by [CBL] ≤ 209 pg/mL. CBL status correlates with microcytosis and anemia. Discordance between [CBL] and [MMA] cautions against relying on any single marker for determining CBL status.Abstract
Background
Objective
Animals
Methods
Results
Conclusions and Clinical Importance
Unknown
Copyright © 2013 by the American College of Veterinary Internal Medicine
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