Effects of Dietary Salt Intake on Renal Function: A 2‐Year Study in Healthy Aged Cats

Journal of Veterinary Internal Medicine

B.S. Reynolds²  V. Chetboul⁶  P. Nguyen³  I. Testault⁵  D.V. Concordet⁴  C. Carlos Sampedrano⁶  J. Elliott⁸  E. Trehiou-Sechi⁶  J. Abadie⁷  V. Biourge¹ 

[1] Royal Canin SAS, Centre de Recherches, Aimargues, France;Unité de Recherche Clinique, Université de Toulouse, INP, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France;Unité de Nutrition et d'Endocrinologie, Oniris, Nantes, France;UMR 1331 Toxalim, INRA, Université de Toulouse, INP, Ecole Nationale Vétérinaire de Toulouse, Toulouse, France;Atlantia Veterinary Hospital, Nantes, France;Unité de Cardiologie d'Alfort, Centre Hospitalier Universitaire Vétérinaire d'Alfort, Université Paris-Est, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, France;Department of Pathology, Oniris, Nantes, France;Department of Veterinary Basic Sciences, Royal Veterinary College, London, UK

关键词: Aldosterone;    Blood pressure;    Glomerular filtration rate;    Kidney;    Salt;   

DOI  :  10.1111/jvim.12074

来源: Wiley

【 摘 要 】

Abstract

Background

Increasing salt intake to promote diuresis has been suggested in the management of feline lower urinary tract disease. However, high dietary salt intake might adversely affect blood pressure and renal function.

Objectives

The objective of this study was to assess the long-term effects of increased salt intake on renal function in healthy aged cats.

Methods

This study was controlled, randomized, and blinded. Twenty healthy neutered cats (10.1 ± 2.4 years) were randomly allocated into 2 matched groups. One group was fed a high salt diet (3.1 g/Mcal sodium, 5.5 g/Mcal chloride) and the other a control diet of same composition except for salt content (1.0 g/Mcal sodium, 2.2 g/Mcal chloride). Clinical examination, glomerular filtration rate, blood pressure measurement, cardiac and kidney ultrasonography, and urinary and blood tests were performed before and over 24 months after diet implementation. Statistics were performed using a general linear model.

Results

Sixteen cats completed the 2 year study. The only variables affected by dietary salt intake were plasma aldosterone and urinary sodium/creatinine ratio, respectively, higher and lower in the control group all over the study period and urinary specific gravity, lower in the high salt diet group at 3 months.

Conclusions and Clinical Importance

Glomerular filtration rate (GFR), blood pressure, and other routine clinical pathological variables in healthy aged cats were not affected by dietary salt content. The results of this 2 year study do not support the suggestion that chronic increases in dietary salt intake are harmful to renal function in older cats.

【 授权许可】

Unknown   
Copyright © 2013 by the American College of Veterinary Internal Medicine