The Immunopathology of Sepsis: Pathogen Recognition, Systemic Inflammation, the Compensatory Anti‐Inflammatory Response, and Regulatory T Cells

Journal of Veterinary Internal Medicine

D.H. Lewis²  D.L. Chan²  D. Pinheiro³  E. Armitage-Chan¹ 

[1] Davies Veterinary Specialists, Manor Farm Business Park, Hertfordshire, SG5 3HR, UK (Armitage-Chan);Department of Veterinary Clinical Sciences, The Royal Veterinary College, Hatfield Campus, Hertfordshire,, UK (Lewis, Chan, Garden);Regulatory T Cell Laboratory, The Royal Veterinary College, Camden Campus, London, NW1 OTU, UK (Pinheiro, Garden)

关键词: Clinical pathology;    Critical care;    Hematology;    Immunology;    Lymphocyte function;    Multiple organ failure;    Shock;   

DOI  :  10.1111/j.1939-1676.2012.00905.x

来源: Wiley

【 摘 要 】

Abstract

Sepsis, the systemic inflammatory response to infection, represents the major cause of death in critically ill veterinary patients. Whereas important advances in our understanding of the pathophysiology of this syndrome have been made, much remains to be elucidated. There is general agreement on the key interaction between pathogen-associated molecular patterns and cells of the innate immune system, and the amplification of the host response generated by pro-inflammatory cytokines. More recently, the concept of immunoparalysis in sepsis has also been advanced, together with an increasing recognition of the interplay between regulatory T cells and the innate immune response. However, the heterogeneous nature of this syndrome and the difficulty of modeling it in vitro or in vivo has both frustrated the advancement of new therapies and emphasized the continuing importance of patient-based clinical research in this area of human and veterinary medicine.

【 授权许可】

Unknown   
Copyright © 2012 by the American College of Veterinary Internal Medicine