Renal Amyloidosis in Dogs: A Retrospective Study of 91 Cases with Comparison of the Disease between Shar‐Pei and Non‐Shar‐Pei Dogs

Journal of Veterinary Internal Medicine

G. Segev²  L. D. Cowgill¹  S. Jessen²  A. Berkowitz²  C.F. Mohr³ 

[1] Department of Medicine and Epidemiology;Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Jerusalem, Israel;Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA

关键词: Canine;    Chronic kidney disease;    Survival;    Amyloid;    Familial Shar‐Pei fever;    Thromboembolism;   

DOI  :  10.1111/j.1939-1676.2011.00878.x

来源: Wiley

【 摘 要 】

Abstract

Background

Renal amyloidosis (RA) is a progressive and fatal renal disease.

Hypothesis

Clinical and pathologic manifestations of RA differ between Chinese Shar-Pei (CSPs) and non-Shar-Pei (NSPs) dogs.

Animals

91 client-owned dogs.

Methods

Retrospective review of medical records of dogs with a histological diagnosis of RA. Clinical and clinicopathologic data, hospitalization, complications, and outcome were compared between CSPs and NSPs.

Results

Comorbid diseases were present in 64% of all dogs. CSPs were significantly younger compared to NSPs (median, 4.8 years; range: 3.6–17 versus median: 9.0 years; range: 2.4–11.1; P < .0001). The frequency of hypoalbuminemia, the most common biochemical abnormality, was higher in NSPs compared to CSPs (100% versus 64.7%, respectively; P < .001). Median serum creatinine concentration at presentation was 5.5 mg/dL, and was 3-fold higher in CSPs compared to NSPs (P = .005). Increased urine protein : creatinine ratio was present in 96% of all dogs. Nephrotic syndrome was present in 10% of NSPs but not in CSPs. Glomerular amyloid deposition, present in both CSPs (78.6%) and NSPs (95.6%) was most commonly diffuse, global, and severe. Renal medullar amyloidosis was more common in CSPs (100%) compared to NSPs (49.0%, P = .002), as was extrarenal amyloid deposition. The median survival time of all dogs was 5 days (range: 0–443 days). Serum creatinine concentration was significantly and negatively associated with survival (P = .025).

Conclusions and Clinical Relevance

The clinical and pathologic manifestations of amyloidosis differ between CSPs and NSPs. The survival time observed herein was unexpectedly low, and argues for early surveillance and management of the underlying predisposing conditions.

【 授权许可】

Unknown   
Copyright © 2012 by the American College of Veterinary Internal Medicine