Proton therapy for lung cancer

Thoracic Cancer

Romaine C. Nichols Jr.¹  Randal H. Henderson¹  Soon Huh¹  Stella Flampouri¹  Zuofeng Li¹  Abubakr A. Bajwa³  Harry J D'Agostino²  Dat C. Pham⁴  Nancy P. Mendenhall¹ 

[1] University of Florida Proton Therapy Institute, Jacksonville, FL, USA;Department of Surgery, University of Florida College of Medicine, Jacksonville, FL, USA;Department of Medicine Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida College of Medicine, Jacksonville, FL, USA;Department of Medical Oncology, University of Florida College of Medicine, Jacksonville, FL, USA

关键词: literature review;    lung cancer;    proton therapy;    radiation therapy;    thoracic tumors;   

DOI  :  10.1111/j.1759-7714.2011.00098.x

来源: Wiley

【 摘 要 】

Abstract

Proton therapy is an emerging radiotherapy technology with the potential to improve the therapeutic index in the treatment of lung cancer patients. Since charged particles, such as protons, have a penetration length that can be modified by using different energies, protons offer the clinician the ability to modulate radiation dose deposition along the beam path. This facilitates an increase of the dose to the tumor target while minimizing the volume of normal tissue irradiation. Such precise delivery is particularly relevant in the setting of lung cancer where the targeted tissues are in close proximity to moderately radiation-sensitive organs like the spinal cord, heart, and esophagus, but are also effectively surrounded by the normal lung, which is extremely sensitive to radiation damage. Proton therapy has been investigated for the treatment of surgically curable yet medically inoperable patients as well as patients with regionally advanced disease.

【 授权许可】

Unknown   
© 2011 Tianjin Lung Cancer Institute and Blackwell Publishing Asia Pty. Ltd