Diffuse large B‐cell lymphoma presenting as large anterior chest wall mass involving pleura and lung: A possible result of post‐traumatic chronic inflammation

Thoracic Cancer

Fouad Atoini¹  Aziz Ouarssani³  Moulay Ahmed Hachimi²  Fatima Aitlhou³  Fatima Zohra Guenoun⁵  Charafeddine Elmejereb⁴  Mustapha Idrissi Rguibi³ 

[1]Department of Thoracic Surgery, Military Hospital Moulay Ismail, Meknes, Morocco

[2]Department of Anesthesiology, Military Hospital Moulay Ismail, Meknes, Morocco

[3]Department of Pulmonology, Military Hospital Moulay Ismail, Meknes, Morocco

[4]Department of Anatomopathology, Military Hospital Moulay Ismail, Meknes, Morocco

[5]Private Centre of Anatomopathology (Laboratory of GUENOUN), Meknes, Morocco

关键词: blunt trauma;    chest wall;    chronic inflammation;    diffuse large B‐cell lymphoma;    lymphoma;   

DOI  :  10.1111/j.1759-7714.2011.00061.x

来源: Wiley

【 摘 要 】

Abstract

A 67 year-old-man was hospitalized due to chronic pain and a large mass on the anterior chest wall. His medical history showed chest trauma in 1970, the reconstitution of the scenario revealed there was blunt trauma with swelling and rib fracture on the same side. Physical examination revealed an isolated large anterior chest wall mass. Chest radiography showed two bilateral irregular masses, chest computed tomography showed a large right chest wall tumor with pleural effusion, nodules of the right upper lobe and tumor of the left lower lobe without mediastinal lymphadenopathy. Whole body exploration showed only the chest disease. Transthoracic biopsy showed inflammatory reaction. Surgical biopsy by anterior thoracotomy of the right mass was performed under general anesthesia. Histological and immunohistological analysis revealed lymphoid diffuse large cell proliferation with positive staining of CD 20, BCL-6 and MUM1, confirming the diagnosis of diffuse large B-cell malignant lymphoma. Chemotherapy based on CHOP-21 (cyclophosphamide, doxorubicin, vincristine, and prednisolone) was administered with good response after three cycles. The patient was discharged under surveillance in good condition after the end of chemotherapy. We report an infrequent neoplasm with an unusual and subtle clinical presentation.

【 授权许可】

Unknown   
© 2011 Tianjin Lung Cancer Institute and Blackwell Publishing Asia Pty. Ltd