Synchronous diffuse large B‐cell lymphoma and squamous cell lung carcinoma

Respirology Case Reports

Masato Fujii²  Toshihiro Shirai²  Kazuhiro Asada²  Yuu Saito¹  Masahide Hirose³ 

[1] Department of Hematology, Shizuoka General Hospital, Shizuoka, Japan;Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan;Department of Thoracic Surgery, Shizuoka General Hospital, Shizuoka, Japan

关键词: 18F‐fluorodeoxyglucose positron emission tomography;    diffuse large B‐cell lymphoma;    squamous cell lung carcinoma;    staging;    synchronous;   

DOI  :  10.1002/rcr2.40

来源: Wiley

【 摘 要 】

Abstract

A 68-year-old woman was referred for a nodule in the right lung and hilar and mediastinal lymphadenopathy. Physical examination revealed left cervical lymphadenopathy. 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) images revealed radiotracer uptake in the pulmonary nodule and multiple lymph nodes of the truncus. Biopsies confirmed the diagnosis of synchronous diffuse large B-cell lymphoma and squamous cell lung carcinoma. Because the etiology of hilar and mediastinal lymphadenopathy was unknown, the staging of lung cancer could not be determined. We performed therapy for malignant lymphoma earlier than lung cancer. After therapy, FDG-PET showed that uptake in the lymph nodes due to lymphoma had disappeared, whereas uptake in the pulmonary nodule and right hilar lymph node remained or had increased. Based on these findings, the staging of lung cancer was determined and radical surgery was performed successfully. This rare case of synchronous malignancy illustrates the limitation of initial single testing of FDG-PET.

【 授权许可】

CC BY-NC   
© 2014 The Authors. Respirology Case Reports published by John Wiley & Sons Ltd on behalf of The Asian Pacific Society of Respirology.

Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.