Coupling blood flow and neural function in the retina: a model for homeostatic responses to ocular perfusion pressure challenge

Physiological Reports

Zheng He¹  Jeremiah K. H. Lim¹  Christine T. O. Nguyen¹  Algis J. Vingrys¹ 

[1] Department of Optometry & Vision Sciences, University of Melbourne, Parkville, Victoria, Australia

关键词: Ocular perfusion pressure;    oxygen extraction ratio;    retinal blood flow;    retinal function;   

DOI  :  10.1002/phy2.55

来源: Wiley

【 摘 要 】

Abstract

Retinal function is known to be more resistant than blood flow to acute reduction of ocular perfusion pressure (OPP). To understand the mechanisms underlying the disconnect between blood flow and neural function, a mathematical model is developed in this study, which proposes that increased oxygen extraction ratio compensates for relative ischemia to sustain retinal function. In addition, the model incorporates a term to account for a pressure-related mechanical stress on neurons when OPP reduction is achieved by intraocular pressure (IOP) elevation. We show that this model, combining ocular blood flow, oxygen extraction ratio, and IOP mechanical stress on neurons, accounts for retinal function over a wide range of OPP manipulations. The robustness of the model is tested against experimental data where ocular blood flow, oxygen tension, and retinal function were simultaneously measured during acute OPP manipulation. The model provides a basis for understanding the retinal hemodynamic responses to short-term OPP challenge.

【 授权许可】

CC BY   
© 2013 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.