Primary choriocarcinoma in mediastinum with multiple lung metastases in a male patient: A case report and a review of the literature

Thoracic Cancer

Song Zhang¹  Hui Gao²  Xin-an Wang³  Bin Liang¹  Dao-wei Li¹  Yang Shao¹ 

[1] Department of Respiratory Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China;Department of Internal Medicine, Shandong Jiao Tong Hospital, Jinan, China;Department of Respiratory, Binzhou People's Hospital, Binzhou, Shandong, China

关键词: Gestational trophoblastic neoplasm;    lung metastases;    primary mediastinal choriocarcinoma;   

DOI  :  10.1111/1759-7714.12120

来源: Wiley

【 摘 要 】

Abstract

Primary choriocarcinoma is a rare malignant tumor, particularly in men. The tumor, mostly found in the gastrointestinal system and mediastinum, often metastasizes early with poor therapeutic effects and prognosis. Herein, we present a male patient with primary mediastinum choriocarcinoma and widespread lung metastases. The disease progressed rapidly with little therapeutic effect from chemotherapy. The patient died of this disease 75 days after initial symptom presentations. Literature review found only 41 cases of primary choriocarcinoma reported in the mediastinum. This case highlights the importance of keeping primary choriocarcinoma in the differentials for mediastinum tumors in young men. Sex hormone testing is helpful to confirm diagnosis. Early biopsy should be performed to confirm pathologic diagnose, and early surgery and chemotherapy should be considered to improve the cure rate of this disease.

【 授权许可】

Unknown   
© 2014 Tianjin Lung Cancer Institute and Wiley Publishing Asia Pty Ltd