Analysis of BIM (BCL‐2 like 11 gene) deletion polymorphism in Chinese non‐small cell lung cancer patients

Thoracic Cancer

Jia Zhong¹  Zheng-Xiang Li¹  Jun Zhao¹  Jian-Chun Duan¹  Hua Bai¹  Tong-Tong An¹  Xiao-Dan Yang¹ 

[1] Department of Thoracic Medical Oncology, Peking University Cancer Hospital & Institute, Beijing, China

关键词: Chemotherapy;    EGFR tyrosine kinase inhibitor;    non‐small cell lung cancer;    polymorphism;   

DOI  :  10.1111/1759-7714.12119

来源: Wiley

【 摘 要 】

Abstract

Background

Drug resistance significantly weakens the efficacy of cancer treatment, and the BIM (also known as the BCL2L11 gene) deletion polymorphism has been identified as a potential biomarker for drug resistance. In this retrospective study, we included a total of 290 patients with advanced non-small cell lung cancer (NSCLC) who received treatment with epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) and chemotherapy.

Methods

The BIM deletion polymorphism of each patient was detected by polymerase chain reaction. EGFR mutations were detected by denaturing high-performance liquid chromatography methods and the amplification refractory mutation system.

Results

The BIM deletion polymorphism was detected in 45/290 (15.5%) Chinese NSCLC patients. No associations were observed between the BIM deletion and clinic-pathologic characteristics of patients. The BIM deletion polymorphism was predictive of shorter progression-free survival in Chinese patients with EGFR-mutant adenocarcinoma and who were treated with EGFR-TKIs (7.30 vs. 9.53 months, P = 0.034). Additionally, we found that the BIM deletion polymorphism was an effective predictor of short progression-free survival in individuals with EGFR-mutant NSCLC and treated with chemotherapy containing pemetrexed (3.32 vs. 5.30, P = 0.012) or second-/beyond-line chemotherapy containing taxanes (1.53 vs. 2.61 months, P = 0.025). The BIM deletion was not correlated with overall survival.

Conclusion

The BIM deletion polymorphism occurs in 15.5% of Chinese NSCLC patients, and is a biomarker for resistance to TKIs and chemotherapy. However, BIM deletion was not a decisive factor in overall survival.

【 授权许可】

Unknown   
© 2014 Tianjin Lung Cancer Institute and Wiley Publishing Asia Pty Ltd