Cover Picture: A Practical One‐Pot Synthesis of Positron Emission Tomography (PET) Tracers via Nickel‐Mediated Radiofluorination (ChemistryOpen 4/2015)

ChemistryOpen

Dr. Boris D. Zlatopolskiy¹  Johannes Zischler¹  Elizaveta A. Urusova¹  Priv.-Doz.𠁝r. Heike Endepols¹  Dr. Elena Kordys¹  Dr. Holm Frauendorf³  Prof.𠁝r. Felix M. Mottaghy² 

[1] Institute of Radiochemistry & Experimental Molecular Imaging, University Clinic Cologne, Cologne, Germany;Clinic of Nuclear Medicine, RWTH Aachen University, Aachen, Germany;Institute of Organic & Biomolecular Chemistry, Georg-August University, Göttingen, Germany

关键词: [18F]fluoride;    nucleophilic aromatic substitution;    positron emission tomography (PET);    radiopharmaceuticals;    radiosynthesis;   

DOI  :  10.1002/open.201580401

来源: Wiley

【 摘 要 】

Abstract

The cover picture shows the differences in brain metabolism of a healthy young and a healthy old subject, as well as a patient suffering from Parkinsons disease (left to right) uncovered by 6-[¹⁸F]FDOPA-positron emission tomography (PET). Morbus Parkinson occurs when nerve cells that produce dopamine begin to die. The shortage of dopamine leads to movement problems in affected individuals. 6-[¹⁸F]FDOPA is extensively used to evaluate the progression of Parkinsons disease. Bold stick projections of this PET tracer, as well as a neuronal network, are seen in the background. Unfortunately, conventional procedures to produce 6-[¹⁸F]FDOPA are cumbersome. Thus, several recent developments aim at the simplification of this radiosynthesis. In our work, we studied the applicability of the recently reported Ni-mediated radiofluorination approach for daily routine production of 6-[¹⁸F]FDOPA. For more details, see the Full Paper on p. 457 ff.

【 授权许可】

Unknown   
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