Synthetic Studies of Alkaloids Containing Pyrrolidine and Piperidine Structural Motifs

ChemistryOpen

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关键词: alkaloids;    asymmetric synthesis;    natural products;    piperidines;    pyrrolidines;   

DOI  :  10.1002/open.201402128

来源: Wiley

【 摘 要 】

Abstract

Avenues to asymmetric alkaloids! Various 2-substituted pyrrolidine and piperidine chiral bioactive natural products were synthesized using a ‘chiral pool’ method. l-proline and l-pipecolinic acids with one chiral center served as the best precursors for the synthesis of these alkaloids. Overall, 14 total synthetic and 11 formal synthetic approaches were developed.

【 授权许可】

CC BY-NC   
© 2014 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.