Targeting the canonical Wnt/β‐catenin pathway in hematological malignancies

Cancer Science

Eishi Ashihara¹  Tetsuya Takada¹ 

[1] Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan

关键词: canonical Wnt pathway;    hematological malignancies;    high‐throughput screening;    small molecule inhibitors;    β‐Catenin;   

DOI  :  10.1111/cas.12655

来源: Wiley

【 摘 要 】

Abstract

The canonical Wnt/β-catenin pathway plays an important role in different developmental processes through the regulation of stem cell functions. In the activation of the canonical Wnt/β-catenin pathway, β-catenin protein is imported into the nucleus and activates transcription of target genes including cyclin D1 and c-myc. Aberrant activation of the Wnt/β-catenin pathway contributes to carcinogenesis and malignant behaviors, and Wnt signaling is essential for the maintenance of cancer stem cells. The canonical Wnt/β-catenin pathway has been investigated extensively as a target in cancer treatment and several specific inhibitors of this signaling pathway have been identified through high-throughput screening. In this review, the significance of the canonical Wnt/β-catenin pathway in hematological carcinogenesis and screening methods for specific inhibitors are discussed.

【 授权许可】

CC BY-NC-ND   
© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.