Reduced risk of breast cancer associated with recreational physical activity varies by HER2 status

Cancer Medicine

Huiyan Ma⁸  Xinxin Xu⁸  Giske Ursin²  Michael S. Simon⁴  Polly A. Marchbanks⁵  Kathleen E. Malone⁷  Yani Lu⁸  Jill A. McDonald³  Suzanne G. Folger⁵  Linda K. Weiss⁹  Jane Sullivan-Halley⁸  Dennis M. Deapen⁶  Michael F. Press¹ 

[1] Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, 90033;Cancer Registry of Norway, Oslo, Norway;College of Health and Social Services, New Mexico State University, Las Cruces, New Mexico;Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan;Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia;Department of Preventive Medicine, University of Southern California, Los Angeles, California, 90033;Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington;Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, California;Cancer Centers Branch, National Cancer Institute, Bethesda, Maryland

关键词: Breast cancer;    ER;    HER2;    luminal A breast cancer;    p53;    physical activity;    PR;    Triple‐negative breast cancer;   

DOI  :  10.1002/cam4.465

来源: Wiley

【 摘 要 】

Abstract

Convincing epidemiologic evidence indicates that physical activity is inversely associated with breast cancer risk. Whether this association varies by the tumor protein expression status of the estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), or p53 is unclear. We evaluated the effects of recreational physical activity on risk of invasive breast cancer classified by the four biomarkers, fitting multivariable unconditional logistic regression models to data from 1195 case and 2012 control participants in the population-based Women's Contraceptive and Reproductive Experiences Study. Self-reported recreational physical activity at different life periods was measured as average annual metabolic equivalents of energy expenditure [MET]-hours per week. Our biomarker-specific analyses showed that lifetime recreational physical activity was negatively associated with the risks of ER-positive (ER+) and of HER2-negative (HER2−) subtypes (both P_trend ≤ 0.04), but not with other subtypes (all P_trend > 0.10). Analyses using combinations of biomarkers indicated that risk of invasive breast cancer varied only by HER2 status. Risk of HER2–breast cancer decreased with increasing number of MET-hours of recreational physical activity in each specific life period examined, although some trend tests were only marginally statistically significant (all P_trend ≤ 0.06). The test for homogeneity of trends (HER2– vs. HER2+ ) reached statistical significance only when evaluating physical activity during the first 10 years after menarche (P_homogeneity = 0.03). Our data suggest that physical activity reduces risk of invasive breast cancers that lack HER2 overexpression, increasing our understanding of the biological mechanisms by which physical activity acts.

【 授权许可】

CC BY   
© 2015 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.