Differences in IGF‐axis protein expression and survival among multiethnic breast cancer patients

Cancer Medicine

Brenda Y. Hernandez²  Lynne R. Wilkens²  Loïc Le Marchand²  David Horio¹  Clayton D. Chong² 

[1] John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii;University of Hawaii Cancer Center, University of Hawaii, Honolulu, Hawaii

关键词: Breast cancer;    IGF1;    IGF1R;    IGFBP2;    IGFBP3;    insulin‐axis protein;    multiethnic;   

DOI  :  10.1002/cam4.375

来源: Wiley

【 摘 要 】

Abstract

There is limited knowledge about the biological basis of racial/ethnic disparities in breast cancer outcomes. Aberrations in IGF signaling induced by obesity and other factors may contribute to these disparities. This study examines the expression profiles of the insulin-like growth factor (IGF)-axis proteins and the association with breast cancer survival across a multiethnic population. We examined the expression profiles of the IGF1, IGF1R, IGFBP2 (IGF-binding proteins), and IGFBP3 proteins in breast tumor tissue and their relationships with all-cause and breast cancer-specific survival up to 17 years postdiagnosis in a multiethnic series of 358 patients in Hawaii, USA. Native Hawaiians, Caucasians, and Japanese were compared. Covariates included demographic and clinical factors and ER/PR/HER2 (estrogen receptor/progesterone receptor/human epidermal growth factor receptor-2) status. In Native Hawaiian patients, IGFBP2 and IGFBP3 expression were each independently associated with overall and breast cancer mortality (IGFB2: HR_mort = 10.96, 95% CI: 2.18–55.19 and HR_mort = 35.75, 95% CI: 3.64–350.95, respectively; IGFBP3: HR_mort = 5.16, 95% CI: 1.27–20.94 and HR_mort = 8.60, 95% CI: 1.84–40.15, respectively). IGF1R expression was also positively associated with all-cause mortality in Native Hawaiians. No association of IGF-axis protein expression and survival was observed in Japanese or Caucasian patients. The interaction of race/ethnicity and IGFBP3 expression on mortality risk was significant. IGF-axis proteins may have variable influence on breast cancer progression across different racial/ethnic groups. Expression of binding proteins and receptors in breast tumors may influence survival in breast cancer patients by inducing aberrations in IGF signaling and/or through IGF-independent mechanisms. Additional studies to evaluate the role of the IGF-axis in breast cancer are critical to improve targeted breast cancer treatment strategies.

【 授权许可】

CC BY   
© 2014 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.