Cancer Medicine | |
A role for G‐CSF and GM‐CSF in nonmyeloid cancers | |
Alexander M. Aliper2  Victoria P. Frieden-Korovkina1  Anton Buzdin2  Sergey A. Roumiantsev2  | |
[1] HiBiotechnology, LLC, Iowa City, Iowa;Federal Clinical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia | |
关键词: Bladder; bone; cancer; colorectal; G‐CSF; glioma; GM‐SF; lung; melanoma; metastasis; prostate; | |
DOI : 10.1002/cam4.239 | |
来源: Wiley | |
【 摘 要 】
Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) modulate progression of certain solid tumors. The G-CSF- or GM-CSF-secreting cancers, albeit not very common are, however, among the most rapidly advancing ones due to a cytokine-mediated immune suppression and angiogenesis. Similarly, de novo angiogenesis and vasculogenesis may complicate adjuvant use of recombinant G-CSF or GM-CSF thus possibly contributing to a cancer relapse. Rapid diagnostic tools to differentiate G-CSF- or GM-CSF-secreting cancers are not well developed therefore hindering efforts to individualize treatments for these patients. Given an increasing utilization of adjuvant G-/GM-CSF in cancer therapy, we aimed to summarize recent studies exploring their roles in pathophysiology of solid tumors and to provide insights into some complexities of their therapeutic applications.Abstract
【 授权许可】
CC BY
© 2014 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
【 预 览 】
Files | Size | Format | View |
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RO202107150001486ZK.pdf | 1365KB | download |