Expression of Eph receptor A10 is correlated with lymph node metastasis and stage progression in breast cancer patients

Cancer Medicine

Kazuya Nagano¹  So-ichiro Kanasaki¹  Takuya Yamashita¹  Yuka Maeda¹  Masaki Inoue¹  Kazuma Higashisaka¹  Yasuo Yoshioka¹  Yasuhiro Abe¹  Yohei Mukai¹  Haruhiko Kamada¹  Yasuo Tsutsumi¹ 

[1] Laboratory of Biopharmaceutical Research, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan

关键词: Breast cancer;    Eph receptor A10;    lymph node metastasis;   

DOI  :  10.1002/cam4.156

来源: Wiley

【 摘 要 】

Abstract

Eph receptor A10 (EphA10) is a valuable breast cancer marker that is highly expressed in breast cancer tissues by comparison with normal breast tissues, as we previously reported. However, the role of EphA10 expression in breast cancer is not well understood. Here, we have analyzed the expression of EphA10 at the mRNA- and protein-level in clinical breast cancer tissues and then evaluated the relationship with clinicopathological parameters for each sample. EphA10 mRNA expression was quantified by real-time polymerase chain reaction using complimentary DNA (cDNA) samples derived from breast cancer patients. Lymph node (LN) metastasis and stage progression were significantly correlated with EphA10 expression at the mRNA level (P = 0.0091 and P = 0.034, respectively). Furthermore, immunohistochemistry (IHC) staining of breast cancer tissue microarrays (TMAs) revealed that EphA10 expression at the protein level was also associated with LN metastasis and stage progression (P = 0.016 and P = 0.011, respectively). These results indicate that EphA10 expression might play a role in tumor progression and metastasis. Our findings will help elucidate the role of EphA10 in clinical breast cancer progression.

【 授权许可】

CC BY   
© 2013 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.