Depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus

Brain and Behavior

Kai G. Kahl³  Ulrich Schweiger²  Christoph Correll¹  Conrad Müller³  Marie-Luise Busch³  Michael Bauer³ 

[1] The Zucker Hillside Hospital, Psychiatry Research, North Shore-Long Island Jewish Health System, Glen Oaks, New York;Department of Psychiatry and Psychotherapy, UK-SH, Lübeck University Medical School, Lübeck, Germany;Department of Psychiatry and Psychotherapy, Carl-Gustav-Carus University, TU Dresden, Germany

关键词: Anxiety disorders;    major depressive disorder;    metabolic syndrome;    mood disorders;    type 2 diabetes mellitus;   

DOI  :  10.1002/brb3.306

来源: Wiley

【 摘 要 】

Abstract

Background

Depressive symptoms have been associated with type 2 diabetes mellitus (T2DM), but less is known about anxiety disorders that can be comorbid or exist without depression.

Methods

We evaluated the prevalence of psychiatric disorders in subjects consecutively examined at an outpatient clinic for diabetes prevention who were at-risk for T2DM, defined by FINDRISK scores, and compared metabolic syndrome (MetS) frequencies between subjects with and without psychiatric morbidity, entering also relevant variables for MetS into multivariate analyses. All subjects underwent an oral glucose tolerance test (OGTT). Psychiatric diagnosis was confirmed using a Structured Clinical Interview for DSM-IV.

Results

Of 260 consecutively screened subjects, 150 (56.9 ± 8.1 years old, males = 56.7%, BMI = 27.2 ± 4.1 kg/m²) were at-risk for T2DM and were included. MetS, present in 27% of males and 25% of females, was significantly associated with having a current anxiety disorder (P < 0.001) and lifetime major depression (P < 0.001). In logistic regression analysis, MetS was significantly associated with lifetime major depression, presence of any anxiety disorder, body weight, and physical activity.

Conclusions

Our data in a high-risk group for T2DM support the association between depressive disorders and MetS, pointing to a similar role of anxiety disorders. Screening for anxiety and depression is recommended in this group at risk for T2DM.

【 授权许可】

CC BY   
© 2015 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.