Aging Cell | |
The influence of skeletal muscle on systemic aging and lifespan | |
Fabio Demontis1  Rosanna Piccirillo2  Alfred L. Goldberg2  | |
[1] Department of Genetics, Harvard Medical School, Boston, MA, USA;Department of Cell Biology, Harvard Medical School, Boston, MA, USA | |
关键词: exercise; intertissue communication during aging; myokine signaling; skeletal muscle aging; systemic aging; | |
DOI : 10.1111/acel.12126 | |
来源: Wiley | |
【 摘 要 】
Epidemiological studies in humans suggest that skeletal muscle aging is a risk factor for the development of several age-related diseases such as metabolic syndrome, cancer, Alzheimer's and Parkinson's disease. Here, we review recent studies in mammals and Drosophila highlighting how nutrient- and stress-sensing in skeletal muscle can influence lifespan and overall aging of the organism. In addition to exercise and indirect effects of muscle metabolism, growing evidence suggests that muscle-derived growth factors and cytokines, known as myokines, modulate systemic physiology. Myokines may influence the progression of age-related diseases and contribute to the intertissue communication that underlies systemic aging.Summary
【 授权许可】
Unknown
© 2013 the Anatomical Society and John Wiley & Sons Ltd
【 预 览 】
Files | Size | Format | View |
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RO202107150000126ZK.pdf | 152KB | download |