The influence of skeletal muscle on systemic aging and lifespan

Aging Cell

Fabio Demontis¹  Rosanna Piccirillo²  Alfred L. Goldberg² 

[1] Department of Genetics, Harvard Medical School, Boston, MA, USA;Department of Cell Biology, Harvard Medical School, Boston, MA, USA

关键词: exercise;    intertissue communication during aging;    myokine signaling;    skeletal muscle aging;    systemic aging;   

DOI  :  10.1111/acel.12126

来源: Wiley

【 摘 要 】

Summary

Epidemiological studies in humans suggest that skeletal muscle aging is a risk factor for the development of several age-related diseases such as metabolic syndrome, cancer, Alzheimer's and Parkinson's disease. Here, we review recent studies in mammals and Drosophila highlighting how nutrient- and stress-sensing in skeletal muscle can influence lifespan and overall aging of the organism. In addition to exercise and indirect effects of muscle metabolism, growing evidence suggests that muscle-derived growth factors and cytokines, known as myokines, modulate systemic physiology. Myokines may influence the progression of age-related diseases and contribute to the intertissue communication that underlies systemic aging.

【 授权许可】

Unknown   
© 2013 the Anatomical Society and John Wiley & Sons Ltd