Frontiers in Medicine | |
D-Limonene Is a Potential Monoterpene to Inhibit PI3K/Akt/IKK-α/NF-κB p65 Signaling Pathway in Coronavirus Disease 2019 Pulmonary Fibrosis | |
Ru Chen1  Zhen-feng Hou2  Ren-shuang Cao3  Xiao-xuan Chen3  Fan Yang3  Hao-yue Zhu3  Wei Zhang4  GuoDong Zang4  Wan-yang Li5  Yu-xuan Li6  | |
[1] Biomedical Research Institute of Fudan University, Shanghai, China;College of Life Sciences, Shandong Normal University, Jinan, China;College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China;Department of Pulmonary Diseases, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China;School of Public Health, Xiangya Medical College, Central South University, Changsha, China;Second School of Clinical Medicine, Beijing University of Chinese Medicine, Beijing, China; | |
关键词: D-limonene; coronavirus disease 2019; coronavirus disease related pulmonary fibrosis; severe acute respiratory syndrome; PI3K/Akt signaling pathway; | |
DOI : 10.3389/fmed.2021.591830 | |
来源: Frontiers | |
【 摘 要 】
At the time of the prevalence of coronavirus disease 2019 (COVID-19), pulmonary fibrosis (PF) related to COVID-19 has become the main sequela. However, the mechanism of PF related to COVID (COVID-PF) is unknown. This study aimed to explore the key targets in the development of COVID-PF and the mechanism of d-limonene in the COVID-PF treatment. The differentially expressed genes of COVID-PF were downloaded from the GeneCards database, and their pathways were analyzed. d-Limonene was molecularly docked with related proteins to screen its pharmacological targets, and a rat lung fibrosis model was established to verify d-limonene's effect on COVID-PF-related targets. The results showed that the imbalance between collagen breakdown and metabolism, inflammatory response, and angiogenesis are the core processes of COVID-PF; and PI3K/AKT signaling pathways are the key targets of the treatment of COVID-PF. The ability of d-limonene to protect against PF induced by bleomycin in rats was reported. The mechanism is related to the binding of PI3K and NF-κB p65, and the inhibition of PI3K/Akt/IKK-α/NF-κB p65 signaling pathway expression and phosphorylation. These results confirmed the relationship between the PI3K–Akt signaling pathway and COVID-PF, showing that d-limonene has a potential therapeutic value for COVID-PF.
【 授权许可】
CC BY
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