Characteristics of Children With Kawasaki Disease-Like Signs in COVID-19 Pandemic: A Systematic Review

Frontiers in Pediatrics

Marzieh Esmaeili¹  Kumars Pourrostami²  Mostafa Qorbani³  Parisa Iravani⁴  Mohammad Esmail Abdar⁵  Parham Mardi⁶ 

[1] Department of Health Information Management, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran;Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran;Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran;Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran;Pediatrics Department, Isfahan University of Medical Sciences, Isfahan, Iran;Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran;Social Determinants of Health Research Center, Alborz University of Medical Sciences, Karaj, Iran;Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran;

关键词: COVID-19;    Kawasaki;    MIS-C;    hyperinflammatory;    children;   

DOI  :  10.3389/fped.2021.625377

来源: Frontiers

【 摘 要 】

Recent studies have shown that several children diagnosed with COVID-19 have developed Kawasaki Disease (KD)-like symptoms. This systematic review aims to assess the demographic, laboratory, and clinical characteristics of children with KD-like syndrome during the COVID-19 pandemic and evaluate efficacy of treatments and patients' outcome. A comprehensive search was carried out systematically through PubMed, Scopus, and Web of Science (WoS), medRxiv, and bioRxiv by two reviewers independently for all studies or preprints data on the demographic, laboratory, and clinical characteristics of children with K.D-like signs during the COVID-19 outbreak. Overall, 378 studies were identified by the systematic search, of which 25 studies were included in the study. The included studies involved 599 patients in total. Thirteen studies (52%) were case reports or case series, and the rest (48%) were cohort studies. In 19 studies, patients were diagnosed with Multisystem inflammatory syndrome in children (MIS-C). In 16 studies COVID-19 was diagnosed in all patients based on their polymerase chain reaction result, serological findings, and computed tomography results. Higher C-reactive protein and erythrocyte sedimentation rate level were the most prevalent laboratory findings. In most studies, patients had leucopenia with marked lymphopenia, hypoalbuminemia, and increased ferritin, as well as hyponatremia. Abnormal echocardiography and respiratory outcomes were the most common clinical outcomes. In 11 studies, all patients required intensive care unit admission. Findings of the present systematic review show that the incidence of KD-like syndrome in the COVID-19 pandemic increased significantly. Moreover, this study offers new insights in the KD-like syndrome pathogenesis and clinical spectrum during COVID-19 pandemic.

【 授权许可】

CC BY