Exercise Training Preserves Myocardial Strain and Improves Exercise Tolerance in Doxorubicin-Induced Cardiotoxicity

Frontiers in Cardiovascular Medicine

Anamaria A. Camargo¹  Roger Chammas²  Igor L. Gomes-Santos³  Camila P. Jordão³  Clevia S. Passos³  Carlos E. Negrão⁴  Patricia C. Brum⁵  Edilamar M. Oliveira⁵ 

[1] Centro de Oncologia Molecular, Hospital Sírio-Libanês, São Paulo, Brazil;Faculdade de Medicina, Cancer Institute of the State of São Paulo (ICESP), Hospital das Clínicas, Universidade de São Paulo, São Paulo, Brazil;Faculdade de Medicina, Heart Institute (InCor), Hospital das Clínicas, Universidade de São Paulo, São Paulo, Brazil;Faculdade de Medicina, Heart Institute (InCor), Hospital das Clínicas, Universidade de São Paulo, São Paulo, Brazil;School of Physical Education and Sport, Universidade de São Paulo, São Paulo, Brazil;School of Physical Education and Sport, Universidade de São Paulo, São Paulo, Brazil;

关键词: exercise;    cardiac function;    speckle tracking;    doxorubicin;    cardiotoxicity;    fatigue;   

DOI  :  10.3389/fcvm.2021.605993

来源: Frontiers

【 摘 要 】

Doxorubicin causes cardiotoxicity and exercise intolerance. Pre-conditioning exercise training seems to prevent doxorubicin-induced cardiac damage. However, the effectiveness of the cardioprotective effects of exercise training concomitantly with doxorubicin treatment remains largely unknown. To determine whether low-to-moderate intensity aerobic exercise training during doxorubicin treatment would prevent cardiotoxicity and exercise intolerance, we performed exercise training concomitantly with chronic doxorubicin treatment in mice. Ventricular structure and function were accessed by echocardiography, exercise tolerance by maximal exercise test, and cardiac biology by histological and molecular techniques. Doxorubicin-induced cardiotoxicity, evidenced by impaired ventricular function, cardiac atrophy, and fibrosis. Exercise training did not preserve left ventricular ejection fraction or reduced fibrosis. However, exercise training preserved myocardial circumferential strain alleviated cardiac atrophy and restored cardiomyocyte cross-sectional area. On the other hand, exercise training exacerbated doxorubicin-induced body wasting without affecting survival. Finally, exercise training blunted doxorubicin-induced exercise intolerance. Exercise training performed during doxorubicin-based chemotherapy can be a valuable approach to attenuate cardiotoxicity.

【 授权许可】

CC BY