Recommendations for Assessment of Environmental Exposures in Longitudinal Life Course Studies Such as the National Children's Study

Frontiers in Pediatrics

Thomas McDade¹  Edith Chen²  Michael Dellarco³  Rosalind Wright⁴  Elaine Faustman⁵  Marissa Smith⁵  Sean Brachvogel⁵  Susan Marie Viet⁶ 

[1] Department of Anthropology, Northwestern University, Evanston, IL, United States;Department of Pscychology, Northwestern University, Evanston, IL, United States;Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States;Icahn School of Medicine at Mount Sinai School, New York, NY, United States;University of Washington, Seattle, WA, United States;Westat, Rockville, MD, United States;

关键词: exposure assessment;    longitudinal research;    environmental exposures;    pediatric longitudinal research;    psychosocial environment;   

DOI  :  10.3389/fped.2021.629487

来源: Frontiers

【 摘 要 】

An important step toward understanding the relationship between the environment and child health and development is the comprehensive cataloging of external environmental factors that may modify health and development over the life course. Our understanding of the environmental influences on health is growing increasingly complex. Significant key questions exist as to what genes, environment, and life stage mean to defining normal variations and altered developmental trajectories throughout the life course and also across generations. With the rapid advances in genetic technology came large-scale genomic studies to search for the genetic etiology of complex diseases. While genome-wide association studies (GWAS) have revealed genetic factors and networks that advance our understanding to some extent, it is increasingly recognized that disease causation is largely non-genetic and reflects interactions between an individual's genetic susceptibility and his or her environment. Thus, the full promise of the human genome project to prevent or treat disease and promote good health arguably depends on a commitment to understanding the interactions between our environment and our genetic makeup and requires a design with prospective environmental data collection that considers critical windows of susceptibility that likely correspond to the expression of specific genes and gene pathways. Unlike the genome, which is static, relevant exposures as well as our response to exposures, change over time. This has fostered the complementary concept of the exposome ideally defined as the measure of all exposures of an individual over a lifetime and how those exposures relate to health. The exposome framework considers multiple external exposures (e.g., chemical, social) and behaviors that may modify exposures (e.g., diet), as well as consequences of environmental exposures indexed via biomarkers of physiological response or measures of behavioral response throughout the lifespan. The exposome concept can be applied in prospective developmental studies such as the National Children's Study (NCS) with the practical understanding that even a partial characterization will bring major advances to health. Lessons learned from the NCS provide an important opportunity to inform future studies that can leverage these evolving paradigms in elucidating the role of environment on health across the life course.

【 授权许可】

CC BY