Impact of the Gut Microbiome on the Progression of Hepatitis B Virus Related Acute-on-Chronic Liver Failure

Frontiers in Cellular and Infection Microbiology

Guoyin Fan¹  Ke Sun²  Lin Long²  Cuiyun Liu²  Haihong Xiang²  Zhiguo Wu²  Aoyu Yang²  Wenlan Gong²  Huili Xu²  Xuebing Yao²  Zhen Gao²  Shuilin Sun²  Haiping Yu²  Wenna Xi²  Mingfa Chen²  Rongyan Yu²  Baogang Xie³  Junrong Liang⁴ 

[1] Department of Infectious Diseases, Nanchang Centers for Disease Control and Prevention, Nanchang, China;Department of Infectious Diseases, The Second Affiliated Hospital of Nanchang University, Nanchang, China;Department of Pharmaceutics, Medical College of Jiaxing University, Jiaxing, China;State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China;

关键词: fecal microbiome;    hepatitis B virus;    acute-on-chronic liver failure;    biomedical indicators;    metabolites;   

DOI  :  10.3389/fcimb.2021.573923

来源: Frontiers

【 摘 要 】

The relationship between the progression of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) and the gut microbiota is poorly understood, and an HBV-ACLF-related microbiome has yet to be identified. In this study alterations in the fecal microbiome of 91 patients with HBV-ACLF (109 stool samples), including a cohort of nine patients at different stages of HBV-ACLF, were determined by high-throughput 16S rDNA sequencing. The operational taxonomic units and Shannon indexes indicated that the diversity and abundance of the gut microbiome significantly decreased with the progression of HBV-ACLF (p <0.05). The relative abundance of the Bacteroidetes phylum in the microbiome was significantly reduced, whereas the abundance of potentially pathogenic bacteria, such as Veilonella, Streptococcus, Enterococcus, and Klebsiella, was highly enriched in the HBV-ACLF group compared with the healthy control group. The abundance of Bacteroidetes was negatively correlated with the level of serum alpha fetoprotein, and the abundance of Veilonella was positively correlated with serum total bilirubin (TBIL). Furthermore, the abundance of Coprococcus was significantly negatively correlated with the level of serum TBIL and the international normalized ratio and positively correlated with prothrombin time activity. Our findings suggest that the gut microbiota plays an important role in the development of HBV-ACLF.

【 授权许可】

CC BY