Mechanisms of Atherosclerosis Induced by Postprandial Lipemia

Frontiers in Cardiovascular Medicine

Longtao Liu¹  Chun Gu²  Guijian Liu²  Limin Pan³  Dan Li³  Yixi Zhao³  Yang Wang³  Min Wu³  Shengjie Yang³  Ran Zhao⁴ 

[1] Cardiovascular Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China;Clinical Laboratory, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China;Comprehensive Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China;Graduate School, Beijing University of Chinese Medicine, Beijing, China;

关键词: postprandial lipemia;    triglyceride;    atherosclerosis;    endothelial dysfunction;    oxidative stress;    inflammation;   

DOI  :  10.3389/fcvm.2021.636947

来源: Frontiers

【 摘 要 】

Postprandial lipemia plays an important role in the formation, occurrence, and development of atherosclerosis, and it is closely related to coronary heart disease and other diseases involving endothelial dysfunction, oxidative stress, inflammation, and other mechanisms. Therefore, it has become a focus area for further research. The studies on postprandial lipemia mainly include TG, TRL, VLDL, CM, and remnant cholesterol. Diurnal triglyceride patterns and postprandial hyperlipidemia are very relevant and are now insufficiently covered. The possible mechanisms between postprandial lipemia and cardiovascular disease have been reviewed in this article by referring to relevant literature in recent years. The research progress on the effects of postprandial lipemia on endothelial function, oxidative stress, and inflammation is highlighted. The intervention of postprandial lipemia is discussed. Non-medicinal intervention such as diet and exercise improves postprandial lipemia. As medicinal intervention, statin, fibrate, ezetimibe, omega-3 fatty acids, and niacin have been found to improve postprandial lipid levels. Novel medications such as pemafibrate, PCSK9, and apoCIII inhibitors have been the focus of research in recent years. Gut microbiota is closely related to lipid metabolism, and some studies have indicated that intestinal microorganisms may affect lipid metabolism as environmental factors. Whether intervention of gut microbiota can reduce postprandial lipemia, and therefore against AS, may be worthy of further study.

【 授权许可】

CC BY