Low Intra-Individual Variation in Mean Platelet Volume Over Time in Systemic Lupus Erythematosus

Frontiers in Medicine

Robin Kahn¹  Lina Wirestam²  Anders A. Bengtsson²  Petrus Linge²  Birgitta Gullstrand²  Helena Tydén²  Andreas Jönsen²  Andreas Jern² 

[1] Section of Pediatrics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden;Wallenberg Centre of Molecular Medicine, Lund University, Lund, Sweden;Section of Rheumatology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden;

关键词: mean platelet volume;    systemic lupus erythematosus;    autoimmunity;    platelets;    biomarkers;   

DOI  :  10.3389/fmed.2021.638750

来源: Frontiers

【 摘 要 】

Platelets have recently emerged as important immune modulators in systemic lupus erythematosus (SLE), in addition to their role in thrombosis and cardiovascular disease. However, studies investigating mean platelet volume (MPV) in SLE are often scarce, conflicting and cross-sectional. In this study, MPV was measured in clinical routine throughout a defined time-period to quantify both individual MPV fluctuations and investigate if such variations are associated with disease activity and clinical phenotypes of SLE. Of our 212 patients, 34 patients had only one MPV value reported with the remaining 178 patients having between 2 and 19 visits with recorded MPV values. The intra-individual MPV variation was low, with a median variation of 0.7 fL. This was further supported by the finding that 84% of patients stayed within their reference interval category (i.e., small, normal or large) over time. In our cohort, no correlation between disease activity and MPV neither cross-sectionally nor longitudinally was found. Mean platelet volume values were significantly smaller in SLE patients (mean 10.5 fL) compared to controls (mean 10.8 fL), p < 0.0001. Based on the reference interval, 2.4% (n = 5) of patients had large-sized platelets, 84.4% (n = 179) had normal-sized and 13.2% (n = 28) had small-sized. A larger proportion (85.7%) of patients with small-sized platelets met the anti-dsDNA criterion (ACR10b; p = 0.003) compared to patients with normal and large (57.6%) sized platelets. In conclusion, the intra-individual MPV variation was of low magnitude and fluctuations in disease activity did not have any significant impact on MPV longitudinally. This lack of variability in MPV over time indicates that measuring MPV at any time-point is sufficient. Further studies are warranted to evaluate MPV as a possible biomarker in SLE, as well as to determine the underlying mechanisms influencing platelet size in SLE.

【 授权许可】

CC BY