Stress Hyperglycemia in Children and Adolescents as a Prognostic Indicator for the Development of Type 1 Diabetes Mellitus

Frontiers in Pediatrics

Theodoros Argyropoulos¹  Stavroula Kostaridou-Nikolopoulou¹  Aristofanis Gikas²  Athanasios Raptis³  Emmanouil Korakas³  Aikaterini Kountouri³  Vaia Lambadiari³ 

[1] Department of Paediatrics, Penteli Children's Hospital, Athens, Greece;Health Center of Kalivia, Athens, Greece;Second Department of Internal Medicine and Research Institute, Medical School, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece;

关键词: stress hyperglycemia;    type 1 diabetes mellitus;    autoantibodies;    inflammation;    environmental factors;   

DOI  :  10.3389/fped.2021.670976

来源: Frontiers

【 摘 要 】

Hyperglycemia is a common manifestation in the course of severe disease and is the result of acute metabolic and hormonal changes associated with various factors such as trauma, stress, surgery, or infection. Numerous studies demonstrate the association of adverse clinical events with stress hyperglycemia. This article briefly describes the pathophysiological mechanisms which lead to hyperglycemia under stressful circumstances particularly in the pediatric and adolescent population. The importance of prevention of hyperglycemia, especially for children, is emphasized and the existing models for the prediction of diabetes are presented. The available studies on the association between stress hyperglycemia and progress to type 1 diabetes mellitus are presented, implying a possible role for stress hyperglycemia as part of a broader prognostic model for the prediction and prevention of overt disease in susceptible patients.

【 授权许可】

CC BY