Influence of NaCl on the Structure and Dynamics of Phospholipid Layers

Frontiers in Physics

Olaf Holderer¹  Henrich Frielinghaus¹  Alexandros Koutsioubas¹  Dominic William Hayward¹  Peter Müller-Buschbaum²  Sebastian Jaksch²  Stephan Förster³  Piotr Zolnierczuk⁴ 

[1] Garching, Germany;Garching, Germany;Garching, Germany;Jülich, Germany;Oak Ridge, TN, United States;

关键词: phospholipids;    salt;    dynamics;    structure;    GISANS;    neutron reflectometry;    neutron spin-echo;    GINSES;   

DOI  :  10.3389/fphy.2021.628219

来源: Frontiers

【 摘 要 】

We present a structural and dynamical analysis of the influence of NaCl on multilayer stacks of phospholipids on a solid surface. To this end, multilayer stacks of phospholipids (L-α-phosphatidylcholine, abbreviated as SoyPC) are investigated with neutron reflectometry, grazing-incidence small-angle neutron scattering (GISANS) and grazing-incidence neutron-spin echo spectroscopy (GINSES). We show both that the NaCl influence on the structure is predominantly on water-head group interface and also, that the change in dynamics is restricted to an associated change in the inter-plane viscosity. Using this knowledge, it is possible to model the dynamical behavior of a phospholipid membrane in response to a salt concentration of the solvent using only a single parameter, namely the in-plane viscosity. The excellent agreement with our previously published model also strongly supports the existence of a thermally excited surface mode in phospholipid membranes for close-to-physiological conditions.

【 授权许可】

CC BY