Elderly Male With Cardiovascular-Related Comorbidities Has a Higher Rate of Fatal Outcomes: A Retrospective Study in 602 Patients With Coronavirus Disease 2019

Frontiers in Cardiovascular Medicine

Margaret H. L. Ng¹  Yuhai Hu²  Qiang Li³  Mo Yang⁴  Liang Li⁴  Huimin Kong⁴  Chun Chen⁴  Xiao-Yong Zhan⁴  Yulong He⁴  Bihui Huang⁴ 

[1] Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China;Department of Clinical Laboratory, Hankou Hospital, Wuhan, China;Department of Clinical Laboratory, Nanfang Hospital, Southern Medical University, Guangzhou, China;The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China;

关键词: COVID-19;    cardiovascular-related comorbidities;    aggressive inflammatory response;    lymphopenia;    elderly male;   

DOI  :  10.3389/fcvm.2021.680604

来源: Frontiers

【 摘 要 】

Elderly with comorbidities have shown a higher rate of fatal outcomes when suffering coronavirus disease 2019 (COVID-19). However, a delineation of clinical significances of hematologic indices and underlying comorbidities in the progression and outcome of COVID-19 remains undefined. Six hundred two COVID-19 patients with established clinical outcomes (discharged or deceased) from Hankou Hospital of Wuhan, China between January 14, 2020 and February 29, 2020 were retrospectively analyzed. Of the 602 patients with COVID-19, 539 were discharged and 63 died in the hospital. The deceased group showed higher leukocyte and neutrophil counts but lower lymphocyte and platelet counts. Longer activated partial thromboplastin time (APTT) and prothrombin time (PT), as well as higher D-dimer and C-reactive protein levels, were found in non-survivors. Our observations suggest that these parameters could serve as potential predictors for the fatal outcome and in the discharged group. A higher neutrophil count and D-dimer level but lower lymphocyte were associated with a longer duration of hospitalization. A multivariable Cox regression analysis showed that higher neutrophil count, prolonged PT, and low lymphocyte count were risk factors for patients with COVID-19. Also, we found an association of lower lymphocyte count and higher C-reactive protein levels with the elderly group and those with cardiovascular-related comorbidities. The significantly different hematologic profiles between survivors and non-survivors support that distinct hematologic signatures in COVID-19 patients will dictate different outcomes as a prognostic marker for recovery or fatality. Lymphopenia and aggressive inflammatory response might be major causes for fatal outcomes in the elderly male and especially those with cardiovascular-related comorbidities.

【 授权许可】

CC BY