Nutritional Support in Malnourished Children With Compromised Gastrointestinal Function: Utility of Peptide-Based Enteral Therapy

Frontiers in Pediatrics

Simge Erdogan¹  Aysugul Alptekin Sarioglu¹  Aydan Kansu²  Mukadder Ayse Selimoglu³  Sema Aydogdu⁴  Buket Dalgic⁵  Aysel Yuce⁶  Fugen Cullu Cokugras⁷ 

[1] Abbott Laboratories, Istanbul, Turkey;Department of Pediatric Gastroenterology, Ankara University School of Medicine, Ankara, Turkey;Department of Pediatric Gastroenterology, Atasehir and Bahcelievler Memorial Hospitals, Istanbul, Turkey;Department of Pediatric Gastroenterology, Ege University Faculty of Medicine, Izmir, Turkey;Department of Pediatric Gastroenterology, Gazi University Faculty of Medicine, Ankara, Turkey;Department of Pediatric Gastroenterology, Hacettepe University Faculty of Medicine, Ankara, Turkey;Department of Pediatric Gastroenterology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey;

关键词: malnutrition;    gastrointestinal function;    children;    nutritional support;    malabsorption;    diarrhea;    peptide-based enteral therapy;   

DOI  :  10.3389/fped.2021.610275

来源: Frontiers

【 摘 要 】

This review focuses on nutritional support in malnourished children with compromised gastrointestinal function addressing the interplay between malnutrition and gastrointestinal dysfunction, and the specific role of peptide-based enteral therapy in pediatric malnutrition. Malnutrition is associated with impaired gut functions such as increased intestinal permeability, malabsorption, and diarrhea, while pre-existing functional gastrointestinal disorders may also lead to malnutrition. Presence of compromised gastrointestinal function in malnourished children is critical given that alterations such as malabsorption and increased intestinal permeability directly interfere with efficacy of nutritional support and recovery from malnutrition. Appropriate nutritional intervention is the key step in the management of malnutrition, while alterations in gastrointestinal functions in malnourished children are likely even in those with mild degree malnutrition. Therefore, nutritional therapy in children with compromised gastrointestinal function is considered to involve gut-protective interventions that address the overlapping and interacting effects of diarrhea, enteropathy and malnutrition to improve child survival and developmental potential in the long-term. Peptide-based enteral formulas seem to have clinical applications in malnourished children with compromised gastrointestinal function, given their association with improved gastrointestinal tolerance and absorption, better nitrogen retention/ balance, reduced diarrhea and bacterial translocation, enhanced fat absorption, and maintained/restored gut integrity as compared with free amino acid or whole-protein formulas.

【 授权许可】

CC BY