Is it appropriate to apply Hertz model to describe cardiac myocytes' mechanical properties by atomic force microscopy nanoindentation?

Micro & nano letters

article

A.A. Soufivand¹  M. Navidbakhsh¹  M. Soleimani² 

[1] Biomechanics Group, School of Mechanical Engineering, Iran University of Science and Technology (IUST);Hematology Group, School of Medical Science, Tarbiat Modares University

关键词: cellular biophysics;    biomechanics;    cardiology;    muscle;    atomic force microscopy;    biological techniques;    nanoindentation;    viscosity;    adhesion;    elastic moduli;    Hertz model application;    cardiac myocyte mechanical property measurement;    atomic force microscopy nanoindentation;    nanoscale precision;    contact mechanics;    AFM indentation force;    AFM indentation depth;    viscous properties;    cell adherence;    elastic modulus extracting method;    nonlinear elastic behaviour;    viscous dissipation;    hyperelastic models;   

DOI  :  10.1049/mnl.2014.0019

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

It was a cold December night in Minneapolis, Minnesota. I was in ICU taking care of a patient, Mr. David, who had had a cardiac arrest at home, underwent CPR and was now on mechanical ventilation. He had been subjected to ‘Mild Induced Hypothermia’ protocol. The patient did well and after re-warming to normal temperature, he was weaned off sedation and mechanical ventilation. He was able to talk and move all his extremities. This is what we hope for in every patient after a cardiac arrest with appropriate medical care and latest technology. Patients get a second lease on life and their loved ones are able to look into their eyes and hold their hands. David’s wife Mary was so happy to see him come around after she had witnessed him undergoing CPR.

【 授权许可】

CC BY|CC BY-ND|CC BY-NC|CC BY-NC-ND