Cardiomyocyte contractile force changes in response to AGRWE detected by AFM

Micro & nano letters

article

YingMin Qu¹  Feihu Zhao²  Xinyue Wang¹  Jinyun Liu¹  Jingmei Li⁴  Zhengxun Song¹  Zuobin Wang¹ 

[1] International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology;Department of Biomedical Engineering, Eindhoven University of Technology;Institute for Research in Applicable Computing, University of Bedfordshire;School of Life Sciences, Changchun University of Science and Technology

关键词: atomic force microscopy;    muscle;    patient treatment;    cardiovascular system;    cellular biophysics;    diseases;    biomechanics;    AGRWE;    single beating cardiomyocytes;    cardiomyocyte contractile force changes;    cardiac contractile force;    American ginseng root water extract;    atomic force microscopy;    contractile strain;    AFM;    cardiovascular disease;    newborn rat;    heart rate;    ginseng agents;    cardiac functions;    heart failure treatment;   

DOI  :  10.1049/mnl.2018.5458

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

This study includes design and synthesis of new non-steroidal anti-inflammatory agents (NSAIDs) with expected cyclooxygenase-2 (COX-2) selective inhibition to achieve better activity and low gastric side effects. Two series of compounds have been designed and synthesized as potential NSAIDs,these  are:     Salicylamide derivatives (compounds 3,4,5 ) and Diflunisal derivatives (compounds 10&11). In vivo acute anti-inflammatory effect of one of the synthesized agents (compound 3)  was evaluated in the rat using egg-white induced paw edema model of inflammation. Preliminary pharmacological study revealed that compound 3 exhibited less anti-inflammatory effect  compared to that of aspirin after 120 and 210 minutes, which encourage the continuation of the search to demonstrate or identify the preliminary pharmacological activity for the  synthesized compounds and to identify their selectivity toward COX-2 isoenzymes.

【 授权许可】

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