【 摘 要 】
Background: The fat embolism syndrome (FES) denotes clinical or subclinical respiratory insufficiency developing in patients with long bone fractures. It usually runs a mild course and responds well to measures for respiratory support. The subclinical form is detected by blood gas analysis and is associated with a PaO2 value of less than 60 mmHg. The present randomized double blind trial was conducted to evaluate the effectiveness of intravenous corticosteroids in comparison with placebo for the prevention of arterial hypoxemia in patients with long bone fractures. Methodology: We conducted a double blinded randomized control trial among 44 patients, who showed signs and symptoms of sub clinical fat embolism and fulfilled our inclusion and exclusion criteria over 2 years period in a tertiary trauma care center. Forty four patients with long bone fractures were randomized as 21 in Group A (placebo group) and 23 in Group B (study group) respectively. The patients in the experimental group received a single dose of 30 mg/kg intravenous methylprednisolone upon admission to the emergency room. The control group received an equal volume of placebo (normal saline).
【 授权许可】
CC BY|CC BY-ND|CC BY-NC|CC BY-NC-ND
【 预 览 】
Files | Size | Format | View |
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RO202107100003770ZK.pdf | 530KB | download |