Micro & nano letters | |
Design and analysis of hairpin piezoresistive pressure sensor with improved linearity using square and circular diaphragms | |
article | |
Mohsen Hayati1  Morteza Fathipour2  Hamid Sherafat Vaziri1  | |
[1] Electrical Engineering Department, Faculty of Engineering, Razi University;Department of Electrical and Computer Engineering, University of Tehran | |
关键词: pressure sensors; diaphragms; resistors; piezoelectric devices; pressure measurement; operational amplifiers; circular diaphragm; square diaphragm; hairpin piezoresistive pressure sensor; flat diaphragm; piezoresistors; OP-AMP amplifier; COMSOL multiphysics software; | |
DOI : 10.1049/mnl.2018.0149 | |
学科分类:计算机科学(综合) | |
来源: Wiley | |
【 摘 要 】
This study designed to prepare ultrafine apixaban (APX) o/w nanoemulsion (NE) based gel with droplet size below 50 nm as a good method for transdermal APX delivery without using permeation enhancer, alternatively, the formulation components itself act as permeation enhancer. APX, a potent oral anticoagulant drug that selectively and directly inhibit coagulation factor Xa, was selected as a good candidate for transdermal delivery as it displays poor water solubility (0.028 mg/mL) and low bioavailability (50%). APX-NE gel was prepared using triacetin, triton-x-100 and carbitol as oil phase, surfactant and cosurfactant respectively, while Carbopol 940 used as a gelling agent. Ex vivo permeation of APX-NE gel through human stratum corneum reveal.
【 授权许可】
CC BY|CC BY-ND|CC BY-NC|CC BY-NC-ND
【 预 览 】
Files | Size | Format | View |
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RO202107100003110ZK.pdf | 461KB | download |