Highly sensitive piezoelectric micromachined ultrasonic transducer operated in air

Micro & nano letters

article

Tao Wang¹  Takeshi Kobayashi³  Chengkuo Lee¹ 

[1] Department of Electrical and Computer Engineering, National University of Singapore;Center for Intelligent Sensors and MEMS, National University of Singapore;National Institute of Advanced Industrial Science and Technology (AIST)

关键词: capacitive transducers;    lead compounds;    ultrasonic transducer arrays;    piezoelectric thin films;    microsensors;    micromachining;    piezoelectric transducers;    frequency 482 kHz;    voltage 2 V;    PZT;    highly sensitive piezoelectric micromachined ultrasonic transducer;    acoustic impedance mismatching;    capacitive micromachined ultrasonic transducer;    portable electronics;    pMUT array;    lead zirconate titanate thin film;    voltage pulses;    piezoelectric constant;    high performance PZT thin film;    displacement sensitivity;    resonant frequency;    in-air transmitting performance;   

DOI  :  10.1049/mnl.2016.0207

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Aims: Trigeminal neuralgia is a rare cause of neuropathic pain and carbamazepine (CBZ) is its main treatment. However, its adverse effects sometimes compel the physicians to substitute or use it concurrently with other drugs. This study aimed to retrospectively compare the effects of combination therapy with pregabalin and carbamazepine versus pregabalin and amitriptyline, in the treatment of patients with refractory trigeminal neuralgia.Methodology: Hospital records of 37 patients with refractory trigeminal neuralgia and no favorable response to the primary treatment without pregabalin, were retrospectively reviewed. Demographic information, drug doses and response to the treatment were recorded in a proforma. Visual Analogue Scale (VAS) was used as the tool for measuring pain intensity. Pain reduction equal or less than 50% based on VAS score after eight weeks of treatment was defined as no response to therapy, and pain reduction of more than 50% was considered as positive response.Results: Twenty eight patients received pregabalin and carbamazepine, three patients received combination of pregabalin and amitriptyline and six received pregabalin, carbamazepine and amitriptyline combination. The mean dose of pregabalin and carbamazepine was 125.68 ± 63.87 and 283.78 ± 193.66 mg/day, respectively. After 8 weeks of treatment, 18 patients (64.3%) in pregabalin and carbamazepine group, six patients (100%) in triple therapy group and two cases (66.7%) in pregabalin and amitriptyline group had responded to treatment.Conclusion: The effect of combination therapy with pregabalin and carbamazepine was comparable with pregabalin and amitriptyline. Using these combinations may be beneficial in patients with severe trigeminal neuralgia unresponsive to primary treatment.

【 授权许可】

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