Renal histopathological alterations induced by nanosilver toxicity: the size effect

Micro & nano letters

article

Mansour Almansour¹  Qais Jarrar²  Abdelkader Battah³  Fatima Obeidat³  Khairat Battah³  Bashir Jarrar⁴ 

[1] Nanotoxicology Center, Deanship of Scientific Research, King Saud University;Pharmacology and Toxicology Department, School of Medicine, Putra University;Pathology and Forensic Medicine Department, School of Medicine, Jordan University;Biology Department, College of Science, Jerash University

关键词: silver;    nanoparticles;    kidney;    biological tissues;    cellular biophysics;    toxicology;    renal histopathological alterations;    nanosilver toxicity;    size effect;    human health;    vital organs;    histopathological changes;    renal tissues;    silver nanoparticles;    male BALB-C mice;    histological processing;    histopathological examination;    glomerular alterations;    tubular alterations;    tubular degeneration;    necrosis;    eosinophilia;    glomerular shrinkage;    Bowman's capsule thickening;    interstitial intertubular regeneration;    mononuclear inflammatory cell infiltration;    proteinaceous casting;    fibrocyte proliferation;    Ag;   

DOI  :  10.1049/mnl.2016.0388

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Background & Objectives: Multi-drug resistance in Staphylococcus aureus and Acinetobacter baumannii (A baumannii) can cause a wide range of infections, including bacteremia, pneumonia, urinary tract infection, peritonitis etc., which can lead to substantial morbidity and mortality, particularly in the ICU settings. These organisms have been shown to be increasingly resistant to a large group of antibiotics, especially β-lactam antibiotics. The aim of the present study was to determine the prevalence and antibiotic susceptibility of methicillin resistant Staphylococcus aureus (MRSA) and A baumannii in patients admitted in Intensive Care Units (ICUs) of a tertiary care hospital in Peshawar, Pakistan. Methodology: A total of 518 bacterial isolates were collected from different ICUs during the period from 1st November 2012 to 30 November 2013. Media, reagents and kits used for bacterial culture and analysis included blood agar, MacConkey’s agar, mannitol salt agar, DNAase and Api Biomerieux 10s (France). Antibiotic cefoxitin was used to check whether strains of Staphylococcus aureus were methicillin resistant or sensitive. The antibiotic susceptibility testing was performed by Mueller Hinton agar (MHA) by disc diffusion method. Results: Out of a total of 518 cultures obtained, 42(8.1%) were MRSA positive and 33(6.37%) were positive for A baumannii. Vancomycin [40(95.23%)] and minocycline [33(78.57%)] were the most effective drugs against MRSA, while colistin [33 (100%)] and minocycline [20 (60.6%)] were the most effective against A baumannii Conclusions: There is an increased frequency of multi-drug resistant Staphylococcus aureus and Acinetobacter baumannii (A baumannii ) among patients in the ICU setting which calls for continuous surveillance to determine prevalence and effective antibiotic susceptibility of these bacteria.

【 授权许可】

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