MEMS-based nanoreactor for in situ analysis of solid–gas interactions inside the transmission electron microscope

Micro & nano letters

article

Hector Hugo Pérez Garza¹  Diederik Morsink¹  Jeff Xu¹  Mariya Sholkina¹  Yevheniy Pivak¹  Merijn Pen¹  Sander van Weperen¹  Qiang Xu¹ 

[1] DENSsolutions B.V.

关键词: chemical reactions;    transmission electron microscopy;    micromechanical devices;    microreactors;    MEMS-based nanoreactor;    solid–gas interaction analysis;    transmission electron microscope;    climate system;    microsized laboratory;    multifunctional sample carrier;    gas experiments;    simultaneous heating experiments;    gas chamber;    microchamber;    electron transparent windows;    low background atomic resolution imaging;    chemical reaction chamber;   

DOI  :  10.1049/mnl.2016.0290

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Objective: This comparative study was designed to assess the efficacy of zolmitriptan, a triptan widely employed asfirst-line therapy for migraine, in relieving post-dural puncture headache in parturients who were operated for cesariansection under spinal anesthesia.Methodology: The study was carried out at department of Anesthesiology, Combined Military Hospital Rawalpindi,over a period of twelve months from August 2012 to July 2013. We enrolled 60 adult parturients who complained ofpost-dural puncture headache in post-partum period. They were divided into two equal groups of 30 each; Group-1(Z-group) received zolmitriptan along with other supportive treatment for spinal headache and Group-2, control group(C-group) was given only supportive treatment. Efficacy of zolmitriptan in relieving post-dural puncture headache(PDPH) was studied and frequency of complications of the drug were noted.Results: After 6 hours, 60% patients of Z-group got relief from headache. While in control group only 36.66% patientswere pain free (p 0.016). After 12 hours, relief from headache was noted in 70% patients of zolmitriptan-group whilein C-group only 46.66% were relieved (p 0.015). After a period of 24 hours results were 86.66% vs. 63.33% (p 0.006).After 48 hours, in Z-group 96.66% patients were pain free, while in C-group 63.33% were free from headache (p 0.001).There was no change in results for Z-group after 72 hours. In contrast, in C-group 80% were pain free and 20% patientswere still symptomatic. Borderline statistical significance was present (p 0.046).Conclusion: The study revealed that anti-migraine drug zolmitriptan in combination with supportive treatment iseffective in relieving PDPH in parturients.

【 授权许可】

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